SALL4在原发性肝癌诊治中的价值

邵玥明; 张雨; 殷鑫; 温晓玉

doi:10.3969/j.issn.1001-5256.2019.10.041

SALL4在原发性肝癌诊治中的价值

DOI: 10.3969/j.issn.1001-5256.2019.10.041

吉林大学第一医院肝胆胰内科

基金项目:

吉林省科技计划项目基金(20190201065JC)；

详细信息

中图分类号: R735.7;R730.43
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- 文章访问数: 1107
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出版历程
- 收稿日期: 2019-05-20
- 出版日期: 2019-10-20

Value of Sal-like 4 in the diagnosis and treatment of primary liver cancer

Department of Hepatology,The First Hospital of Jilin University

Research funding:

摘要

摘要: SALL4是一种维持干细胞自我更新和多能性的转录因子。它在胎肝中表达但在成年人肝脏中表达沉默。目前已发现SALL4在多种实体瘤中具有诊断价值。这些特征赋予了它作为肝癌肿瘤标志物的可能。回顾了近年来SALL4在原发性肝癌发生、进展、转移等生物学过程中的作用,及其对原发性肝癌预后的预测作用。随着研究的深入,SALL4及相关microRNA可能成为诊断、治疗原发性肝癌及预测预后的新型标志物。
- 肝肿瘤 /
- SALL4 /
- 诊断 /
- 治疗学
Abstract: Sal-like 4(SALL4) is a transcription factor that helps to maintain self-renewal and pluripotency of stem cells. This gene is expressed in the human fetal liver,but is silent in the healthy adult liver. It has been reported that SALL4 has a diagnostic value in a variety of solid tumors. These characteristics make SALL4 a possible tumor biomarker for liver cancer. This article reviews the recent advances in the role of SALL4 in the development,progression,metastasis,and other biological processes of primary liver cancer,as well as its role in predicting the prognosis of primary liver cancer. We believe that with further studies,SALL4 and related microRNAs may become new markers for the diagnosis,treatment,and prognostic evaluation of primary liver cancer.
- liver neoplasms /
- SALL4 /
- diagnosis /
- therapeutics

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参考文献(25)

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