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HBV cccDNA检测技术与临床应用

张宇 赵景民

引用本文:
Citation:

HBV cccDNA检测技术与临床应用

DOI: 10.3969/j.issn.1001-5256.2019.10.002
基金项目: 

国家自然科学基金(81673654); 

详细信息
  • 中图分类号: R512.62

Clinical application of covalently closed circular DNA detection techniques

Research funding: 

 

  • 摘要: 共价闭合环状DNA(cccDNA)是HBV复制的原始模板,是HBV持续性感染的基础,只有彻底清除HBV cccDNA,才能真正清除HBV,因此HBV cccDNA的检测对评价慢性乙型肝炎抗病毒疗效、病毒清除、明确隐匿性HBV感染、研究乙型肝炎致病机制以及新药的研发等方面具有重要的意义,而建立灵敏度高且特异度好的HBV cccDNA检测技术是实现其临床应用价值的基础。基于文献报道,结合团队相关研究工作,对HBV cccDNA检测方法的发展及其临床应用进行综合评述。

     

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  • 收稿日期:  2019-08-01
  • 出版日期:  2019-10-20
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