血清学标志物在肝硬化门静脉高压无创评估中的应用

肖鹏; 张亚南; 巴桃桃; 丁梦梦; 高沿航

doi:10.3969/j.issn.1001-5256.2019.09.042

血清学标志物在肝硬化门静脉高压无创评估中的应用

DOI: 10.3969/j.issn.1001-5256.2019.09.042

吉林大学第一医院肝胆胰内科

基金项目:

“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项(2017ZX10202202,2018ZX10302206)；国家重点研发计划“精准医学研究”专项(2017YFC0908103)；吉林省自然科学基金(20160101097JC)；吉林大学高层次创新团队建设项目(2017TD-08)；中央高校基本科研业务费专项资金；

详细信息

中图分类号: R575.2
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出版历程
- 收稿日期: 2019-04-23
- 出版日期: 2019-09-20

Application of serological markers in noninvasive assessment of cirrhotic portal hypertension

Department of Hepatobiliary and Pancreatic Medicine, The First Hospital of Jilin University

Research funding:

摘要

摘要: 门静脉高压最常见的病因为各种原因所致的肝硬化,门静脉压力达到一定程度,将出现脾大、腹水、肝性脑病及食管静脉曲张破裂出血等严重临床并发症,危及患者生命,因此评估门静脉高压对代偿期肝硬化患者的诊断及失代偿期肝硬化患者的治疗和预后至关重要。由于评估门静脉高压的"金标准"肝静脉压力梯度有创、昂贵,门静脉高压无创评估成为当前研究热点。利用血清学标志物无创评估门静脉高压具有简单、易行、可重复的优点,评估门静脉高压的血清学标志物日益受到关注。随着对肝硬化门静脉高压发病机制认识的深入,血清学标志物的研究日益增多,主要包括促炎细胞因子、细胞外基质成分及其循环降解产物等。总结及评述了血清学标志物在门静脉高压无创评估中的进展,以期对临床更早期、更便捷诊断门静脉高压提供帮助。
- 肝硬化 /
- 高血压,门静脉 /
- 生物标记
Abstract: The most common cause of portal hypertension is liver cirrhosis due to various reasons. When portal venous pressure reaches a certain level, serious clinical complications can endanger patient's life, such as splenomegaly, ascites, hepatic encephalopathy, and esophageal variceal bleeding. Therefore, diagnosis and evaluation of portal hypertension is crucial for the diagnosis of patients with compensated cirrhosis and the treatment and prognosis of patients with decompensated cirrhosis. As the gold standard for the evaluation of portal hypertension, hepatic venous pressure gradient is invasive and highly expensive, and thus noninvasive evaluation of portal hypertension has become a research hotspot in recent years. Noninvasive evaluation of portal hypertension based on serological markers is simple, easy, and reproducible, and such serological markers have attracted more and more attention. With in-depth studies on the pathogenesis of cirrhotic portal hypertension, there is an increasing number of studies on serological markers, mainly including pro-inflammatory cytokines, extracellular matrix components, and their cyclic degradation products. This article summarizes and elaborates on the research advances in the role of serological markers in noninvasive assessment of portal hypertension, in order to provide help for early and convenient diagnosis of portal hypertension.
- liver cirrhosis /
- hypertension, portal /
- biomarkers

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参考文献(30)

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