进一步加强肝衰竭的临床与基础研究

韩涛; 刘磊

doi:10.3969/j.issn.1001-5256.2019.09.001

进一步加强肝衰竭的临床与基础研究

DOI: 10.3969/j.issn.1001-5256.2019.09.001

韩涛,
刘磊

天津市第三中心医院肝内科天津市人工细胞重点实验室天津市肝胆疾病研究所卫生部人工细胞工程技术研究中心天津医科大学三中心临床学院

基金项目:

国家科技重大专项(2017ZX10203201-007)；国家自然科学基金面上项目(81870429)；

详细信息

中图分类号: R575.3
计量
- 文章访问数: 1074
- HTML全文浏览量: 20
- PDF下载量: 342
- 被引次数: 0
出版历程
- 收稿日期: 2019-05-29
- 出版日期: 2019-09-20

Further strengthen the clinical and basic research on liver failure

Han Tao,
Liu Lei

Department of Hepatology, Tianjin Third Central Hospital;Tianjin Key Laboratory of Artificial Cells;Tianjin Institute of Hepatobiliary Disease; Artificial Cell Engineering Technology Research Center of Public Health Ministry; The Third Central Clinical College of Tianjin Medical University

Research funding:

摘要

摘要: 肝衰竭是临床常见的严重肝病临床症候群,病死率高。近些年来肝衰竭的研究虽然已经取得了很大进展,但仍然有不少问题尚存在一些分歧,如肝衰竭的分类、诊断标准及治疗等,发病机制需要进一步阐明,新的诊治策略需要进一步探索。因此,需要进一步加强肝衰竭的临床与基础研究,从而提升肝衰竭的综合诊治水平,不断降低肝衰竭病死率。
- 肝功能衰竭 /
- 发病机制 /
- 病理状态,体征和症状 /
- 治疗学
Abstract: Liver failure is a severe clinical syndrome of liver disease with high mortality. Although great achievements have been made in the research on liver failure in recent years, there are still controversies over many issues including the classification, diagnostic criteria, and treatment of liver failure. The pathogenesis of liver failure needs to be further clarified, and innovative strategies for diagnosis and treatment need to be further explored. Therefore, the clinical and basic research on liver failure should be further strengthened to improve the comprehensive diagnosis and treatment level of liver failure and continuously reduce the mortality rate of liver failure.
- liver failure /
- pathogenesis /
- pathological conditions, signs and symptoms /
- therapeutics

HTML全文

参考文献(14)

[1] Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. Guideline for diagnosis and treatment of liver failure (2018) [J]. J Clin Hepatol, 2019, 35 (1) :38-44. (in Chinese) 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南 (2018年版) [J].临床肝胆病杂志, 2019, 35 (1) :38-44.

[2] TANDON BN, BERNAUAU J, O’GRADY J, et al. Recommendations of the international association for the study of the liver subcommittee on nomenclature of acute and subacute liver failure[J]. J Gastroenterol Hepatol, 1999, 14 (5) :403-404.

[3] European Association for the Study of the Liver. EASL clinical practical guidelines on the management of acute (fulminant) liver failure[J]. J Hepatol, 2017, 66 (5) :1047-1081.

[4] ZHANG Q, LI Y, HAN T, et al. Comparison of current diagnostic criteria for acute-on-chronic liver failure[J]. PLo S One, 2015, 10 (3) :e0122158.

[5] MAHMUD N, KAPLAN DE, TADDEI TH, et al. Incidence and mortality of acute on chronic liver failure using two definitions in patients with compensated cirrhosis[J]. Hepatology, 2019, 69 (5) :2150-2163.

[6] LEAO GS, LUNARDA FL, PICON RV, et al. Acute-on-chronic liver failure:A comparison of three different diagnostic criteria[J]. Ann Hepatol, 2019, 18 (2) :373-378.

[7] JALAN R, YURDAYDIN C, BAJAJ JS, et al. Toward an improved definition of acute-on-chronic liver failure[J]. Gastroenterology, 2014, 147 (1) :4-10.

[8] WU T, LI J, SHAO L, et al. Development of diagnostic criteria and a prognostic score for hepatitis B virus-related acute-on-chronic liver failure[J]. Gut, 2018, 67 (12) :2181-2191.

[9] BAJAJ JS, MOREAU R, KAMATH PS, et al. Acute-onchronic liver failure:Getting ready for prime time?[J]. Hepatology, 2018, 68 (4) :1621-1632.

[10] JORGENSEN I, RAYAMAJHI M, MIAO EA. Programmed cell death as a defence against infection[J]. Nat Rev Immunol, 2017, 17 (3) :151-164.

[11] TRIANTAFYLLOU E, WOOLLARD KJ, MCPHAIL MJW, et al.The role of monocytes and macrophages in acute and acuteon-chronic liver failure[J]. Front Immunol, 2018, 9 (12) :2948.

[12] SINGAL AK, SHAH VH. Current trials and novel therapeutic targets for alcoholic hepatitis[J]. J Hepatol, 2019, 70 (2) :305-313.

[13] LARSEN FS. Artificial liver support in acute and acute-onchronic liver failure[J]. Curr Opin Crit Care, 2019, 25 (2) :187-191.

[14] ARROYO V. Acute-on-chronic liver failure in cirrhosis requires expedited decisions for liver transplantation[J]. Gastroenterology, 2019, 156 (5) :1248-1249.

施引文献

资源附件(0)

访问统计