Treg/Th17、Th1/Th2平衡在自身免疫性肝炎中的免疫学机制及诊疗新靶点

王维钊; 向晓星

doi:10.3969/j.issn.1001-5256.2019.08.051

Treg/Th17、Th1/Th2平衡在自身免疫性肝炎中的免疫学机制及诊疗新靶点

DOI: 10.3969/j.issn.1001-5256.2019.08.051

大连医科大学消化内科
苏北人民医院扬州大学临床医学院消化内科

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中图分类号: R575.1
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出版历程
- 收稿日期: 2019-02-26
- 出版日期: 2019-08-20

Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment

Department of Gastroenterology, Dalian Medical University

摘要

摘要: 自身免疫性肝炎(AIH)是一种发生在肝脏的慢性自身免疫性疾病,临床主要表现为自身抗体阳性,转氨酶异常升高,高丙种球蛋白血症。目前的研究显示,调节性T淋巴细胞(Treg)/辅助性T淋巴细胞(Th) 17、Th1/Th2失衡是AIH发生发展机制之一。而OX40与其配体OX40L是肿瘤坏死因子家族的成员,二者结合作为T淋巴细胞活化的协同性刺激因子参与免疫应答,能够调节Treg/Th17、Th1/Th2平衡,影响多种自身免疫性疾病进程。但目前其在AIH的研究鲜有报道。查阅相关文献,围绕Treg/Th17、Th1/Th2平衡在AIH中的作用及免疫诊疗新靶点OX40/OX40L与AIH的潜在关系作一综述。
- 肝炎,自身免疫性 /
- T淋巴细胞,调节性 /
- T淋巴细胞,辅助诱导
Abstract: Autoimmune hepatitis (AIH) is a chronic autoimmune disease in the liver, with major clinical manifestations of positive autoantibody, abnormal elevation of aminotransferases, and hypergammaglobulinemia. Current studies have shown that regulatory T (Treg) /T helper17 (Th17) and T helper 1 (Th1) /T helper 2 (Th2) imbalance is one of the mechanisms of the development and progression of AIH. OX40 (also known as CD134, TNFRSF4, or ACT35) and its ligand OX40 L are members of the tumor necrosis factor family, and they participate in immune response as co-stimulators of T cell activation and can regulate Treg/Th17 and Th1/Th2 balance, thus affecting the progression of various autoimmune diseases. However, there are few reports on the role of OX40 and OX40 L in AIH. With reference to related articles, this article reviews the role of Treg/Th17 and Th1/Th2 balance in AIH and the potential association between OX40/OX40 L (new targets for immunological diagnosis and treatment) and AIH.
- hepatitis, autoimmune /
- T-lymphocytes, regulatory /
- T-lymphocytes, helper-inducers

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