重症肝病患者医院感染的临床特征与危险因素

张丹; 冯国和

doi:10.3969/j.issn.1001-5256.2019.01.047

重症肝病患者医院感染的临床特征与危险因素

DOI: 10.3969/j.issn.1001-5256.2019.01.047

张丹,
冯国和

中国医科大学附属盛京医院感染性疾病肝病科

详细信息

中图分类号: R575
计量
- 文章访问数: 1268
- HTML全文浏览量: 9
- PDF下载量: 265
- 被引次数: 0
出版历程
- 出版日期: 2019-01-20

Current research status of nosocomial infection in patients with severe liver diseases

Department of Infectious Diseases and Hepatology, Shengjing Hospital of China Medical University, Shenyang 110021, China

摘要

摘要:
重症肝病患者由于肝功能严重障碍,机体免疫功能低下,对感染应激能力下降,病程中易发生医院感染,而各种感染又进一步加重病情,直接影响患者的临床转归。综述了重症肝病患者医院感染的临床特点及危险因素。
- 肝疾病 /
- 交叉感染 /
- 危险因素 /
- 综述
Abstract:
Patients with severe liver diseases are prone to nosocomial infection due to serious liver dysfunction, low immune function, and reduced stress ability to infection, and such infections further aggravate patients’conditions and directly affect their clinical outcome.This article reviews the clinical features of nosocomial infection in patients with severe liver diseases and related risk factors.
- liver diseases /
- cross infection /
- risk factors /
- review

HTML全文

参考文献(37)

[1]ZHAO H, SHI Y, DONG H, et al.Community-or healthcareassociated bacterial infections increase long-term mortality in patients with acute decompensation of cirrhosis[J].Am J Med Sci, 2018, 355 (2) :132-139.

[2]Ministry of Health of the People’s Republic of China.Diagnostic criteria for nosocomial infection (on trial) [J].Natl Med JChina, 2001, 81 (5) :314-320. (in Chinese) 中华人民共和国卫生部.医院感染诊断标准 (试行) [J].中华医学杂志, 2001, 81 (5) :314-320.

[3]ZHANG D, ZHOU YM.Risk factors for healthcare-associated infection in patients with severe viral hepatitis[J].Chin J Infect Control, 2017, 16 (7) :654-657. (in Chinese) 张丹, 周一萌.重型病毒性肝炎医院感染的危险因素[J].中国感染控制杂志, 2017, 16 (7) :654-657.

[4]YANG W, ZHAO C, LI ZX, et al.Analysis of clinical characteristics of hospital infections in patients with liver failure[J].Chin JNosocomiol, 2015, 25 (20) :4701-4702, 4708. (in Chinese) 杨伟, 赵超, 李增新, 等.肝衰竭患者医院感染的临床特征分析[J].中华医院感染学杂志, 2015, 25 (20) :4701-4702, 4708.

[5]TANG GH, JIANG D.Incidence and risk factors for healthcareassociated infection in patients with liver cirrhosis[J].Chin J Infect Control, 2015, 14 (5) :329-331. (in Chinese) 汤国红, 蒋丹.肝硬化患者医院感染率及危险因素[J].中国感染控制杂志, 2015, 14 (5) :329-331.

[6]JIANG S, LI F, WU J, et al.Investigation and analysis on hospital infection of 386 cases with severe hepatitis[J/CD].Chin J Liver Dis:Electronic Edition, 2015, 7 (1) :80-82. (in Chinese) 江山, 李飞, 吴君, 等.386例重型肝炎医院感染调查分析[J/CD].中国肝脏病杂志:电子版, 2015, 7 (1) :80-82.

[7]ZHANG XH, HAN QL, ZHANG YT.Risk factors for nosocomial infection in patient with liver disease[J].J Guiyang Med Coll, 2014, 39 (6) :935-936, 939. (in Chinese) 张小河, 韩秋丽, 张优惕.肝病区患者发生医院感染的危险因素[J].贵阳医学院学报, 2014, 39 (6) :935-936, 939.

[8]XING YM, FENG D, ZHOU RJ.Risk factors of nosocomial infections in patients with cirrhosis[J].Chin J Nosonomiol, 2014, 24 (16) :4041-4042, 4045. (in Chinese) 邢益门, 冯端, 周仁精.肝硬化患者医院感染的危险因素分析[J].中华医院感染学杂志, 2014, 24 (16) :4041-4042, 4045.

[9]WANG X, PENG CX, YE CJ, et al.Risk factors for nosocomial infections in patients with liver cirrhosis and prevention countermeasures[J].Chin J Nosocomiol, 2015, 25 (1) :169-170, 173. (in Chinese) 汪鑫, 彭春仙, 叶程军, 等.肝硬化患者医院感染的危险因素分析与预防[J].中华医院感染学杂志, 2015, 25 (1) :169-170, 173.

[10]BOLIA R, SRIVASTAVA A, MARAK R, et al.Prevalence and impact of bacterial infections in children with liver disease-a prospective study[J].J Clin Exp Hepatol, 2018, 8 (1) :35-41.

[11]XIE Y, TU B, ZHANG X, et al.Investigation on outcomes and bacterial distributions of liver cirrhosis patients with gramnegative bacterial bloodstream infection[J].Oncotarget, 2017, 9 (3) :3980-3995.

[12]GU X, JING XM, LI L, et al.Characteristics and risk factors for healthcare-associated infection in patients with severe chronic hepatitis B[J].Chin J Infect Control, 2016, 15 (7) :518-520, 523. (in Chinese) 古雪, 敬雪明, 李铃, 等.慢性重型乙型肝炎患者医院感染特点及危险因素[J].中国感染控制杂志, 2016, 15 (7) :518-520, 523.

[13]HASSAN EA, ELSHERBINY NM, ABD EL-REHIM AS, et al.Health care-associated infections in pre-transplant liver intensive care unit:perspectives and challenges[J].J Infect Public Health, 2018, 11 (3) :398-404.

[14]ZHANG WX, PAN YJ, ZHANG Q, et al.Analysis on risk factors of nosocomial infection in liver specialist hospital of Guangzhou[J].Mod Hosp, 2016, 16 (4) :567-569. (in Chinese) 张文先, 潘越峻, 张青, 等.肝病医院医院感染的危险因素分析[J].现代医院, 2016, 16 (4) :567-569.

[15]REN N, WEN XM, WU AH.Nationwide cross-sectional survey on healthcare-associated infection in 2014[J].Chin J Infect Control, 2016, 15 (2) :83-87. (in Chinese) 任南, 文细毛, 吴安华.2014年全国医院感染横断面调查报告[J].中国感染控制杂志, 2016, 15 (2) :83-87.

[16]DENG NM, WANG H, WANG J, et al.Prevalence rates of healthcare-associated infection in a comprehensive hospital from 2012 to 2014[J].Chin J Infect Control, 2015, 14 (11) :786-788. (in Chinese) 邓乃梅, 王虹, 王锦, 等.2012-2014年某综合医院感染现患率调查[J].中国感染控制杂志, 2015, 14 (11) :786-788.

[17]GUO YX, XU YJ, FU YJ, et al.The analysis of the characteristics and the related factors of nosocomial infections in patients with liver cirrhosis[J].Chin J Nosocomiol, 2014, 24 (11) :2748-2749, 2759. (in Chinese) 郭玉香, 徐叶进, 付跃娟, 等.肝硬化患者医院感染特点及相关因素分析[J].中华医院感染学杂志, 2014, 24 (11) :2748-2749, 2759.

[18]LEI W, HUANG JJ, LI XP, et al.Clinical characteristics of chronic severe hepatitis B combined with nosocomial infections and its related factors[J].Inter J Epeidemiol Infect Dis, 2014, 41 (6) :392-395. (in Chinese) 雷弯, 黄娟君, 李小鹏, 等.慢性乙型重型肝炎医院感染的临床特点及相关因素分析[J].国际流行病学传染病学杂志, 2014, 41 (6) :392-395.

[19]XU ZY.Clinical features of patients with liver cirrhosis and nosocomial infection[J].Chin Pract J Rural Doct, 2016, 23 (4) :59-61. (in Chinese) 徐志勇.肝硬化合并医院感染的临床特征分析[J].中国实用乡村医生杂志, 2016, 23 (4) :59-61.

[20]SHIZUMA T.Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis:A literature review[J].World JHepatol, 2018, 10 (2) :254-266.

[21]LI YT, YU CB, HUANG JR, et al.Pathogen profile and drug resistance analysis of spontaneous peritonitis in cirrhotic patients[J].World J Gastroenterol, 2015, 12 (36) :10409-10417.

[22]XIE Y, TU B, XU Z, et al.Bacterial distributions and prognosis of bloodstream infections in patients with liver cirrhosis[J].Sci Rep, 2017, 7 (1) :11482.

[23]PARKER R, IM G, JONES F, et al.Clinical and microbiological features of infection in alcoholic hepatitis:an international cohort study[J].J Gastroenterol, 2017, 52 (11) :1192-1200.

[24]LIU YZ, MIN XX, FAN YL.The study of risk factors of nosocomial infections for patients with severe viral hepatitis[J].Chin J Nosocomiol, 2015, 25 (16) :3751-3753. (in Chinese) 刘玉柱, 闵祥玺, 樊艳丽.重型病毒性肝炎患者医院感染危险因素研究[J].中华医院感染学杂志, 2015, 25 (16) :3751-3753.

[25]ZHANG GH, WANG M, WANG L, et al.An analysis of clinical characteristic and related risk factors in 208 cirrhotic patients complicated with infections[J].Chin J Intern Med, 2018, 57 (2) :118-122. (in Chinese) 张冠华, 王民, 王岚, 等.208例肝硬化合并感染患者的临床特点及相关因素分析[J].中华内科杂志, 2018, 57 (2) :118-122.

[26]FIORE M, MARAOLO AE, GENTILE I, et al.Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multidrug resistance pathogens:A systematic review[J].World JGastroenterol, 2017, 23 (25) :4654-4660.

[27]KONG SH, LIANG JG, ZHANG CS, et al.Drug resistance of pathogens causing nosocomial infections in patients with severe liver disease[J].Chin J Nosocomiol, 2017, 27 (2) :330-332. (in Chinese) 孔双红, 梁建国, 张才仕, 等.重症肝病患者医院感染病原菌的耐药性分析[J].中华医院感染学杂志, 2017, 27 (2) :330-332.

[28]FREEMAN J, MCGOWAN JE JR.Differential risk of nosocomial infection[J].Am J Med, 1981, 70 (4) :915-918.

[29]CHEN TF, YAN QM, QIN M, et al.Risk factors for nosocomial infections in patients with decompensated hepatitis B liver cirrhosis[J].Chin J Nosocomiol, 2015, 25 (12) :2787-2789. (in Chinese) 陈庭富, 严琦敏, 秦明, 等.失代偿期慢性乙型肝炎肝硬化患者医院感染研究[J].中华医院感染学杂志, 2015, 25 (12) :2787-2789.

[30]HAN XH, SHEN XS, JIANG HQ, et al.Clinical risk factors for nosocomial infections in patients with severe viral hepatitis[J].Chin J Nosocomiol, 2016, 26 (5) :991-993. (in Chinese) 韩秀华, 沈雪松, 姜海琼, 等.重型病毒性肝炎患者医院感染的临床危险因素分析[J].中华医院感染学杂志, 2016, 26 (5) :991-993.

[31]HU XX, YANG X.Hospital infection risk factors and intervention studies in severe viral infection patients[J].Chin J Nosocomiol, 2014, 24 (11) :2745-2747. (in Chinese) 胡秀霞, 杨雪.重型病毒性肝炎患者医院感染危险因素分析及干预研究[J].中华医院感染学杂志, 2014, 24 (11) :2745-2747.

[32]HAN JP, YA CM, YOU W.Risk factors causing nosocomial infections to patients with liver diseases[J].Chin J Nosocomiol, 2014, 24 (10) :2491-2492, 2499. (in Chinese) 韩津萍, 轧春妹, 尤炜.肝病患者医院感染的危险因素分析[J].中华医院感染学杂志, 2014, 24 (10) :2491-2492, 2499.

[33]LUO LH, ZHAO JM, XIA L, et al.Risk factors for nosocomial infections in patients with decompensated cirrhosis patients[J].Chin J Nosocomiol, 2014, 24 (10) :2497-2499. (in Chinese) 罗灵和, 赵建民, 夏亮, 等.失代偿期肝硬化患者医院感染的危险因素探讨[J].中华医院感染学杂志, 2014, 24 (10) :2497-2499.

[34]ZHANG ZB, CHEN LH.Role of risk assessment model based on Logistic regression analysis in preventing nosocomial infection[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition, 2018, 12 (3) :230-234. (in Chinese) 张泽波, 陈莉华.基于Logistic回归分析的风险评估对医院感染的预防作用[J/CD].中华实验和临床感染病杂志:电子版, 2018, 12 (3) :230-234.

[35]ZHANG MF, MU XY.Artificial liver plasma exchange treatment of 15 patients with severe hepatitis hospital infection analysis and prevention[J].Shanxi Med J, 2014, 43 (3) :271-273. (in Chinese) 张名芳, 牧小亚.人工肝血浆置换治疗重型肝炎医院感染15例分析及预防[J].山西医药杂志, 2014, 43 (3) :271-273.

[36]WAN CG, GUO Y, YOU HQ, et al.Risk factors for nosocomial infections in patients with liver cirrhosis and prevention countermeasures[J].Chin J Nosocomiol, 2014, 24 (2) :406-407, 410. (in Chinese) 万橱根, 郭艳, 尤华强, 等.肝硬化患者医院感染危险因素分析及预防对策[J].中华医院感染学杂志, 2014, 24 (2) :406-407, 410.

[37]CHOUDHURI AH, KHURANA P, BISWAS PS, et al.Epidemiology and risk factors for multidrug-resistant bacteria in critically ill patients with liver disease[J].Saudi J Anaesth, 2018, 12 (3) :389-394.

施引文献

资源附件(0)

访问统计