不同类型肝窦阻塞综合征的临床特征、发病机制与诊治

刘贞利; 范作鹏; 勾钰淞; 柳雅立; 张晶

doi:10.3969/j.issn.1001-5256.2019.01.046

不同类型肝窦阻塞综合征的临床特征、发病机制与诊治

DOI: 10.3969/j.issn.1001-5256.2019.01.046

首都医科大学附属北京佑安医院丙型肝炎与中毒性肝病科

基金项目:

艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2018ZX10715005-003-003)；

详细信息

中图分类号: R575
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出版历程
- 出版日期: 2019-01-20

Clinical features, pathogenesis, and diagnosis and treatment of different types of hepatic sinusoidal obstruction syndrome

Department of Hepatitis C & Toxic Liver Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China

Research funding:

摘要

摘要:
肝窦阻塞综合征(HSOS)是一种肝窦或肝小静脉纤维闭塞性疾病,肝小血管损伤特别是肝窦内皮细胞损伤为其主要特征。接触某些外源性毒性物质是其主要致病原因。根据病因不同,HSOS主要包括以下类型:吡咯生物碱相关肝窦阻塞综合征;造血干细胞移植相关肝窦阻塞综合征;其他病因不明的肝窦阻塞综合征。对HSOS不同分类进行概述,简述了HSOS的临床表现、发病机制、诊断和治疗等方面的研究进展。
- 肝静脉闭塞性疾病 /
- 生物碱类 /
- 造血干细胞移植 /
- 综述
Abstract:
Hepatic sinusoidal obstruction syndrome (HSOS) is a sinusoidal or small venous fibrous occlusive disease characterized by small hepatic vessel damage, especially sinusoidal endothelial cell injury.Exposure to certain exogenous toxins is the main cause of the disease.Based on etiology, HSOS is mainly classified into pyrrolidine alkaloid-related HSOS, hematopoietic stem cell transplantation-related HSOS, and HSOS of unknown etiology.This article summarizes the types of HSOS and reviews the research advances in clinical manifestations, pathogenesis, diagnosis, and treatment of HSOS.
- hepatic veno-occlusive disease /
- alkaloids /
- hematopoietic stem cell transplantation /
- review

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参考文献(54)

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