非酒精性脂肪性肝病相关肝细胞癌的研究进展

桂文芳; 朱清静; 杨玲

doi:10.3969/j.issn.1001-5256.2018.12.040

非酒精性脂肪性肝病相关肝细胞癌的研究进展

DOI: 10.3969/j.issn.1001-5256.2018.12.040

1. 华中科技大学同济医学院附属协和医院消化内科
2. 华中科技大学同济医学院附属协和医院超声影像科
3. 武汉市医疗救治中心肝病科

基金项目:

国家自然科学基金(81570530,81370550,30500658)；武汉卫生和计划生育委员会科研课题(WXD18D30)；

详细信息

中图分类号: R575;R735.7
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出版历程
- 出版日期: 2018-12-20

Research advances in nonalcoholic fatty liver disease-related hepatocellular carcinoma

Research funding:

摘要

摘要: 随着肥胖以及其他代谢综合征发病率的增高,目前非酒精性脂肪性肝病(NAFLD)已经成为最常见的慢性肝脏疾病之一。越来越多的研究表明NAFLD是肝细胞癌的危险因素之一,但NAFLD发展成为肝细胞癌的机制尚未完全阐明。近年研究显示肠道微生态失衡、炎症反应、脂肪因子、胰岛素抵抗、高胰岛素血症、脂肪祖细胞以及遗传基因的突变等参与了NAFLD相关肝癌的发生。现阶段针对NAFLD的治疗措施主要有运动饮食干预、胰岛素增敏剂、抗氧化剂、益生菌以及降脂药等,这些治疗方法能否有效预防NAFLD相关肝细胞癌尚不清楚。综述了近年来NAFLD相关肝细胞癌的流行情况、发病机制、预防、监测及筛查。
- 非酒精性脂肪性肝病 /
- 肝肿瘤 /
- 综述
Abstract: With the increase in the incidence rates of obesity and other metabolic syndromes, nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases. More and more studies have shown that NAFLD is one of the risk factors for hepatocellular carcinoma (HCC) , but the mechanism of NAFLD in HCC remains unclear. Recent studies have found that intestinal microflora imbalance, inflammatory response, adipokines, insulin resistance, hyperinsulinemia, adipose progenitor cells, and genetic mutation are involved in the development of NAFLD-related HCC. Major treatment methods for NAFLD include exercise and diet intervention, insulin sensitizer, antioxidants, probiotics, and lipid-lowering drugs. However, it is still unknown whether these methods can effectively prevent NAFLD-related HCC. This article reviews recent advances in the prevalence, pathogenesis, prevention, monitoring, and screening of NAFLD-related HCC.
- nonalcoholic fatty liver disease /
- liver neoplasms /
- review

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