肝肾综合征早期生物学标志物的研究进展

陈兰兰; 韩文; 刘京京; 呼丹; 贺唯唯

doi:10.3969/j.issn.1001-5256.2018.11.040

肝肾综合征早期生物学标志物的研究进展

DOI: 10.3969/j.issn.1001-5256.2018.11.040

延安大学附属医院消化内科

详细信息

中图分类号: R575.3;R692
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出版历程
- 出版日期: 2018-11-20

Research advances in the biomarkers for the early diagnosis of hepatorenal syndrome

摘要

摘要: 肝肾综合征（HRS）是终末期肝病患者的严重并发症之一,Ⅰ、Ⅱ型HRS短期病死率均较高,预后不良。局限于血清肌酐的HRS诊断标准存在明显的滞后性,如何实现早期诊断对HRS的治疗及预后尤为重要。介绍了目前国内外研究较多的7项肾损伤生物学标志物在HRS早期诊断、鉴别诊断、预后评估中的应用价值及临床意义。指出了中性粒细胞明胶酶相关脂质运载蛋白、IL-18、肾损伤分子-1可能是适用于肝硬化患者早期肾损伤检测的生物学标志物,多项生物指标、影像及介入技术互相协作、联合应用是未来HRS早期检测的可行方法。
- 肝肾综合征 /
- 生物学标记 /
- 综述
Abstract: Hepatorenal syndrome ( HRS) is one of the most serious complications of end-stage liver disease. Type Ⅰ/Ⅱ HRS has a high short-term mortality rate and poor prognosis. The diagnostic criteria for HRS based on serum creatinine cannot keep up with the world, and early diagnosis is of great importance to the treatment and prognosis of HRS. This article introduces the value and clinical significance of seven biomarkers for renal injury in the early diagnosis, differential diagnosis, and prognostic evaluation of HRS. It is pointed out that neutrophil gelatinase-associated lipocalin, interleukin-18, and kidney injury molecule-1 may be the biomarkers for early identification of renal injury in patients with liver cirrhosis. A combination of multiple biological indicators, imaging examination, and interventional techniques might be a feasible method for early diagnosis of HRS in future.
- hepatorenal syndrome /
- biological markers /
- review

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参考文献(38)

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