HBV A1762T/G1764A双核苷酸替换与肝脏疾病的关系

赖欣; 周太成; 韦嘉

doi:10.3969/j.issn.1001-5256.2018.09.034

HBV A1762T/G1764A双核苷酸替换与肝脏疾病的关系

DOI: 10.3969/j.issn.1001-5256.2018.09.034

1. 昆明医科大学第四附属医院肝病内科
2. 昆明医科大学第四附属医院中心实验室

基金项目:

云南省教育厅科学研究基金(2017YJS086)；

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2018-03-20
- 出版日期: 2018-09-20

Association between HBV A1762T/G1764A double nucleotide substitution and liver diseases

Department of Liver Disease, The Fourth Affiliated Hospital of Kunming Medical University

Research funding:

摘要

摘要: HBV A1762T/G1764A双核苷酸替换(又称TA突变)在肝脏疾病中比较常见。肝细胞核因子(HNF4)是肝脏富集转录因子之一,TA突变刚好位于HNF4与HBV相结合的区域,在HBV基因的转录和复制中发挥重要的调节作用。有研究认为TA突变可能会加重HBV感染后肝脏疾病病情,增加慢性肝衰竭及肝癌风险,但如何加重HBV感染后疾病病情尚不明确,值得进一步研究。就HBV A1762T/G1764A双核苷酸替换与肝病的关系进行了综述。
- 肝炎病毒,乙型 /
- 变异(遗传学) /
- 综述
Abstract: HBV A1762 T/G1764 A double nucleotide substitution (also called TA mutation) is relatively common in liver diseases. Hepatocyte nuclear factor 4 (HNF4) is one of liver-enriched transcription factors, and TA mutation is located in the binding region of HNF4 and HBV and plays an important regulatory role in HBV gene transcription and replication. Several studies have pointed out that TA mutation may aggravate liver diseases after HBV infection and increase the risk of chronic liver failure and liver cancer; however, it is still unclear how TA mutation can aggravate liver disease after HBV infection, and more studies are needed for clarification in the future. This article reviews the association between HBV A1762 T/G1764 A double nucleotide substitution and liver diseases.
- hepatitis B virus /
- variation (genetics) /
- review

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参考文献(32)

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