慢性乙型肝炎及肝硬化患者血清高迁移率族蛋白B1水平变化及临床意义

杨新英; 康富标; 叶立红; 戴二黑; 孙殿兴

doi:10.3969/j.issn.1001-5256.2018.09.015

慢性乙型肝炎及肝硬化患者血清高迁移率族蛋白B1水平变化及临床意义

DOI: 10.3969/j.issn.1001-5256.2018.09.015

1. 解放军白求恩国际和平医院肝病传染科
2. 石家庄市第五医院病理科

详细信息

中图分类号: R512.62;R575.2
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出版历程
- 收稿日期: 2018-04-25
- 出版日期: 2018-09-20

Level of high-mobility group box 1 in patients with chronic hepatitis B and liver cirrhosis and its clinical significance

Department of Infectious Liver Diseases, Bethune International Peace Hospital

摘要

摘要: 目的探讨慢性乙型肝炎患者血清高迁移率族蛋白B1（HMGB1）水平与肝脏炎症活动程度、肝纤维化程度及肝功能各指标的关系。方法选取2015年5月-2016年5月于白求恩国际和平医院和石家庄市第五医院就诊的73例慢性乙型肝炎及肝硬化患者作为研究对象,肝活组织检查确定炎症活动程度及纤维化程度,检测肝功能相关指标及血清HMGB1,分析HMGB1水平与各指标的相关性。2组间比较采用t检验,两指标间的相关性采用直线相关性分析。结果慢性乙型肝炎及肝硬化患者血清HMGB1水平[（29.46±7.54）ng/ml]较健康对照组[（16.86±3.48）ng/ml]明显升高,2组间比较差异有统计学意义（t=5.668,P<0.01）。G3G4组HMGB1水平显著高于G1G2组（t=4.441,P<0.01）,但S1S2组HMGB1水平与S3S4组无明显差异（t=0.658,P>0.05）。血清HMGB1水平与ALT（r=0.256 6,P=0.028 4）及AST（r=0.471 9,P<0.00...
- 肝炎,乙型,慢性 /
- 肝硬化 /
- HMGB1蛋白质
Abstract: Objective To investigate the correlation of serum high-mobility group box 1 (HMGB1) level with hepatic inflammatory activity, liver fibrosis degree, and liver function parameters in chronic hepatitis B patients. Methods A total of 73 patients with chronic hepatitis B and liver cirrhosis were enrolled as subjects. Liver biopsy was performed to determine inflammatory activity and liver fibrosis degree, liver function parameters and serum HMGB1 level were measured, and the correlation between HMGB1 level and other indices was analyzed. The t-test was used for comparison between two groups, and a linear correlation analysis was performed to investigate the correlation between two indices. Results The patients with chronic hepatitis B and liver cirrhosis had a significantly higher HMGB1 level than the healthy control group (29. 46 ± 7. 54 ng/ml vs 16. 86 ± 3. 48 ng/ml, t = 5. 668, P < 0. 01) . The G3-G4 group had a significantly higher HMGB1 level than the G1-G2 group (t = 4. 441, P < 0. 01) , while there was no significant difference in HMGB1 level between the S1-S2 group and the S3-S4 group (t = 0. 658, P > 0. 05) . Serum HMGB1 level was positively correlated with alanine aminotransferase (r = 0. 256 6, P = 0. 028 4) and aspartate aminotransferase (r = 0. 471 9, P < 0. 000 1) , while it was not correlated with albumin or total bilirubin (both P > 0. 05) . Conclusion Serum HMGB1 level is closely correlated with hepatic inflammatory activity.
- hepatitis B, chronic /
- liver cirrhosis /
- HMGB1 protein

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