EB病毒性肝炎的研究进展

黄姜伟; 韩方正

doi:10.3969/j.issn.1001-5256.2018.06.043

EB病毒性肝炎的研究进展

DOI: 10.3969/j.issn.1001-5256.2018.06.043

徐州医科大学附属医院感染性疾病科

详细信息

中图分类号: R512.6
计量
- 文章访问数: 2776
- HTML全文浏览量: 73
- PDF下载量: 435
- 被引次数: 0
出版历程
- 收稿日期: 2017-11-20
- 出版日期: 2018-06-20

Research advances in Epstein-Barr viral hepatitis

Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University

摘要

摘要: EB病毒性肝炎是由EB病毒感染引起的肝脏炎症反应,大多数为自限性肝炎或轻中度肝损伤,预后良好,少数可发展为慢性肝病、重型肝炎,甚至肝内胆管细胞癌等。该病的临床表现及组织病理学特征缺乏特异性,容易漏诊、误诊,需要引起临床医师更多的关注与重视。介绍了EB病毒的感染机制以及EB病毒性肝炎的相关研究进展。
- 疱疹病毒4型,人 /
- 肝炎,病毒性,人 /
- 综述
Abstract: Epstein-Barr virus hepatitis is liver inflammation caused by Epstein-Barr virus infection, mainly self-limited hepatitis or mild or moderate liver injury. It often has good prognosis, but it may progress to chronic liver disease, severe hepatitis, and even intrahepatic cholangiocarcinoma. The clinical manifestations and histopathological features of this disease lack specificity, which may lead to missed diagnosis or misdiagnosis, and thus it should be taken seriously by clinicians. This article introduces the mechanism of Epstein-Barr virus infection and reviews the research advances in Epstein-Barr viral hepatitis.
- herpesvirus 4, human /
- hepatitis, viral, human /
- review

HTML全文

参考文献(42)

[1]YOUNG LS, YAP LF, MURRAY PG.Epstein-Barr virus:more than50 years old and still providing surprises[J].Nat Rev Cancer, 2016, 16 (12) :789-802.

[2]KOFTERIDIS DP, KOULENTAKI M, VALACHIS A, et al.Epstein Barr virus hepatitis[J].Eur J Intern Med, 2011, 22 (1) :73-76.

[3]LI M, GAO RP.Investigation and characteristics of Epstein-Barr virus infection among patients with different liver diseases[D].Changchun:Jilin Univ, 2016. (in Chinese) 李敏, 高润平.不同肝病Epstein-Barr virus感染的调查及临床特点分析[D].长春:吉林大学, 2016.

[4]RAO SC, ASHRAF I, MIR F, et al.Dual infection with hepatitis B and Epstein-Barr virus presenting with severe jaundice, coagulopathy, and hepatitis B virus chronicity outcome[J].Am J Case Rep, 2017, 18:170-172.

[5]SUN K, XU S, WEI J, et al.Clinicopathological features of 11 Epstein-Barr virus-associated intrahepatic cholangiocarcinoma at a single center in China[J].Medicine, 2016, 95 (40) :e5069.

[6] WANG XM, TONG M, XU C, et al.Research progress of Epstein-Barr virus-related disease[J].Chin Clin Pract Med, 2016, 7 (3) :98-101. (in Chinese) 王雪萌, 童梅, 徐晨, 等.EB病毒感染及相关疾病的研究进展[J].中国临床实用医学, 2016, 7 (3) :98-101.

[7]TIAN QH, ZHU SX.Research progress of Epstein-Barr virus-related disease in infants[J].Int J Virol, 2017, 24 (1) :69-72. (in Chinese) 田巧焕, 朱淑霞.儿童EB病毒感染及其相关常见疾病研究进展[J].国际病毒学杂志, 2017, 24 (1) :69-72.

[8]ABBOTT RJ, PACHNIO A, PEDROZA-PACHECO I, et al.Asymptomatic primary infection with Epstein-Barr virus:Observations on young adult cases[J].J Virol, 2017, 91 (21) :e00382-17.

[9]KIMURA H, NAGASAKA T, HOSHINO Y, et al.Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes.[J].Human Pathol, 2001, 32 (7) :757-762.

[10]GRU AA, HAVERKOS BH, FREUD AG, et al.The EpsteinBarr virus (EBV) in T cell and NK cell lymphomas:Time for a reassessment[J].Curr Hematol Malig Rep, 2015, 10 (4) :456-467.

[11]MA S, GUO SB, DU TK, et al.Analysis on clinical characteristics and assess immune function of adult with EBV infection[D].Beijing:Peking Union Med Coll, 2016. (in Chinese) 马帅, 郭树彬, 杜铁宽, 等.EBV感染成人临床特点分析及免疫功能评价[D].北京:北京协和医学院, 2016.

[12]ZHANG H, LI SJ, YUAN YH, et al.The correlation of the liver damage induced by Epstein-Barr virus infection with peripheral blood lymphocyte subsets[J].J Clin Pediatr, 2013, 31 (3) :233-235. (in Chinese) 张慧, 李双杰, 袁远宏, 等.EB病毒感染肝脏损伤与外周血淋巴细胞亚群相关性[J].临床儿科杂志, 2013, 31 (3) :233-235.

[13]WORTH AJ, HOULDCROFT CJ, BOOTH C.Severe EpsteinBarr virus infection in primary immunodeficiency and the normal host[J].Br J Haematol, 2016, 175 (4) :559-576.

[14]HOSOI H, SONOKI T, MURATA S, et al.Successful immunosuppressive therapy for severe infectious mononucleosis in a patient with clonal proliferation of EBV-infected CD8-positive cells[J].Intern Med, 2015, 54 (12) :1537-1541.

[15]CABIBI D.Autoimmune hepatitis following Epstein-Barr virus infection[J].BMJ Case Rep, 2008, 2008:bcr0620080071.

[16]LI XJ, QU LJ, ZHENG XW, et al.Clinicopathologic features of chronic active Epstein-Barr virus hepatitis[J].World Chin J Dig, 2013, 21 (23) :2325-2330. (in Chinese) 李鑫静, 曲利娟, 郑雄伟, 等.慢性活动性EB病毒性肝炎的临床病理特征[J].世界华人消化杂志, 2013, 21 (23) :2325-2330

[17]CRUM NF.Epstein Barr virus hepatitis:case series and review[J].South Med J, 2006, 99 (5) :544-547.

[18]SUH N, LIAPIS H, MISDRAJI J, et al.Epstein-Barr virus hepatitis:diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients.[J].Am J Surg Pathol, 2007, 31 (9) :1403-1409.

[19]YAN W, LI J, REN YY, et al.The levels of liver enzymes and atypical lymphocytes are higher in youth patients with infectious mononucleosis than in preschool children[J].Clin Mol Hepatol, 2013, 19 (4) :382-388.

[20]TAN ZH, PHUA KB, ONG C, et al.Prolonged hepatitis and jaundice:a rare complication of paediatric Epstein-Barr virus infection[J].Singapore Med J, 2015, 56 (7) :e112-e115.

[21]LEONARDSSON H, HREINSSON JP, LVE A, et al.Hepatitis due to Epstein-Barr virus and cytomegalovirus:clinical features and outcomes[J].Scand J Gastroenterol, 2017, 52 (8) :893-897.

[22]VINE LJ, SHEPHERD K, HUNTER JG, et al.Characteristics of Epstein-Barr virus hepatitis among patients with jaundice or acute hepatitis[J].Aliment Pharmacol Ther, 2012, 36 (1) :16-21.

[23]SALVA I, SILVA I V, CUNHA F.Epstein-Barr virus-associated cholestatic hepatitis[J].BMJ Case Rep, 2013, 2013:bcr2013202213.

[24]GUPTA E, BHATIA V, CHOUDHARY A, et al.Epstein-Barr virus associated acute hepatitis with cross-reacting antibodies to other herpes viruses in immunocompetent patients:report of two cases.[J].J Med Virol, 2013, 85 (3) :519-523.

[25]SHAUKAT A, TSAI HT, RUTHERFORD R, et al.Epstein-Barr virus induced hepatitis:An important cause of cholestasis[J].Hepatol Res, 2005, 33 (1) :24-26.

[26]PETROVA M, KAMBUROV V.Epstein-Barr virus:silent companion or causative agent of chronic liver disease?[J].World J Gastroenterol, 2010, 16 (33) :4130-4134.

[27]TIAN ZS, WEN XY, WANG CY, et al.Severe liver damage caused by chronic active Epstein-Barr virus infection in children:A report of one ease[J].J Clin Hepatol, 2015, 31 (9) :1488-1489. (in Chinese) 田宗升, 温晓玉, 王重阳, 等.慢性活动性EB病毒感染致严重肝损伤1例报告[J].临床肝胆病杂志, 2015, 31 (9) :1488-1489.

[28]GAO JX, HUANG Y.Liver cirrhosis caused by chronic active Epstein-Barr virus infection in children:A report of one case[J].Mod J Integr Tradit Chin West Med, 2009, 18 (30) :3758-3759. (in Chinese) 高建兴, 黄莹.慢性活动性EB病毒感染致肝硬化1例[J].现代中西医结合杂志, 2009, 18 (30) :3758-3759.

[29]QIANG CQ, GENG GH, XU CX, et al.Analysis on the clinical characteristics and prognosis of 104 patients with liver function damage caused by Epstein-Barr virus infection[J/CD].Chin J Exp Clin Infect Dis:Electronic Edition, 2014, 8 (3) :410-413. (in Chinese) 强春倩, 荆国红, 徐学彩, 等.104例EB病毒感染肝功能损害患者的临床特点及预后分析[J/CD].中华实验和临床感染病杂志:电子版, 2014, 8 (3) :410-413.

[30]SAADAH OI, BOKHARY RY.Anti-mitochondrial antibody positive autoimmune hepatitis triggered by EBV infection in a young girl[J].Arab J Gastroenterol, 2013, 14 (3) :130-132.

[31]DU HL, SHENG YJ, LI Y, et al.Clinical analysis of 29 cases of EB virus induced hepatitis[J].J Luzhou Med Coll, 2016, 39 (2) :148-150. (in Chinese) 都泓莲, 盛云建, 李烨, 等.EB病毒性肝炎29例临床分析[J].泸州医学院学报, 2016, 39 (2) :148-150.

[32]PODDIGHE D.Epstein-Barr virus hepatitis:importance of PCR assay/serology and significance ofγ-GTP[J].Pediatr Int, 2017, 59 (8) :947-947.

[33]DREBBER U, KASPER HU, KRUPACZ J, et al.The role of Epstein-Barr virus in acute and chronic hepatitis[J].J Hepatol, 2006, 44 (5) :879-885.

[34]JIANG ZF, SHEN KL, SHEN Y.Zhu Futang:Practical paidonosology[M].The 8th Edition.Beijing:People's Medical Publishing House, 2015:916-921. (in Chinese) 江载芳, 申昆玲, 沈颖.诸福棠实用儿科学[M].第8版.北京:人民卫生出版社, 2015:916-921.

[35]LU HY, WEI XQ, XU XY, et al.A study of the relationship between EBV DNA and EBV antibody levels[J].J Clin Hepatol, 2015, 31 (5) :766-770. (in Chinese) 陆海英, 魏秀琴, 徐小元, 等.EBV抗体与EBV DNA水平的影响因素及其相关性分析[J].临床肝胆病杂志, 2015, 31 (5) :766-770.

[36]YANG YY, WANG XH, WAN G, et al.Clinical features of liver injury associated with acute Epstein-Barr virus infection inadults:An analysis of 115 cases[J].J Clin Hepatol, 2017, 33 (6) :1141-1144. (in Chinese) 杨玉英, 王欣慧, 万钢, 等.115例成人急性EB病毒感染相关肝损伤临床特征分析[J].临床肝胆病杂志, 2017, 33 (6) :1141-1144.

[37]RAFAILIDIS PI, MAVROS MN, KAPASKELIS A, et al.Antiviral treatment for severe EBV infections in apparently immunocompetent patients.[J].J Clin Virol, 2010, 49 (3) :151-157.

[38]ONTANILLA CG, PRAENA SJ, GIRLDEZ G, et al.Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus.[J].Rev Esp Enferm Dig, 2017, 109 (5) :388-390.

[39] RAFAILIDIS PI, MAVROS MN, KAPASKELIS A, et al.Antiviral treatment for severe EBV infections in apparently immunocompetent patients.[J].J Clin Virol, 2010, 49 (3) :151-157.

[40]MELLINGER JL, ROSSARO L, NAUGLER WE, et al.Epstein-Barr virus (EBV) related acute liver failure:A case series from the US acute liver failure study group[J].Dig Dis Sci, 2014, 59 (7) :1630-1637.

[41]NAKAZAWA A, NAKANO N, FUKUDA A, et al.Use of serial assessment of disease severity and liver biopsy for indication for liver transplantation in pediatric Epstein-Barr virus-induced fulminant hepatic failure[J].Liver Transpl, 2015, 21 (3) :362-368.

[42]ADER F, CHATELLIER D, LE BR, et al.Fulminant EpsteinBarr virus (EBV) hepatitis in a young immunocompetent subject[J].Med Mal Infect, 2006, 36 (7) :396-398.

施引文献

资源附件(0)

访问统计