梗阻性黄疸动物模型的研究进展

骆伟伟; 余水平

doi:10.3969/j.issn.1001-5256.2017.09.043

梗阻性黄疸动物模型的研究进展

DOI: 10.3969/j.issn.1001-5256.2017.09.043

1. 桂林医学院
2. 桂林医学院附属医院

基金项目:

广西壮族自治区科技攻关计划(2015jjAA40027)；

详细信息

中图分类号: R-332;R575
计量
- 文章访问数: 1968
- HTML全文浏览量: 52
- PDF下载量: 487
- 被引次数: 0
出版历程
- 收稿日期: 2017-03-13
- 出版日期: 2017-09-20

Research advances in animal models of obstructive jaundice

Guilin Medical University

Research funding:

摘要

摘要: 梗阻性黄疸是一类常见疾病,严重危害人类健康。为了更好的研究梗阻性黄疸的发病机制、疾病发展过程中的病理生理变化及治疗措施,建立稳定的梗阻性黄疸动物模型成为研究各类梗阻性黄疸的基础。阐述并分析了急性、渐进性、慢性波动性、恶性和可复性5种梗阻性黄疸模型的优缺点和应用现状,各类模型体现目的疾病的发生发展过程存在一定的局限性。大多数模型是通过手术或外界物理化学损伤引起,尚无基因敲除或过表达小鼠模型。未来的工作重点在于摸索稳定的慢性、渐进性和特殊类型的梗阻性黄疸动物模型。
- 黄疸,阻塞性 /
- 模型,动物 /
- 综述
Abstract: Obstructive jaundice is a common disease that greatly threatens human health. In order to better investigate the pathogenesis of obstructive jaundice, pathophysiological changes during disease progression, and treatment measures, the establishment of a stable animal model of obstructive jaundice becomes the basis for the research on various types of obstructive jaundice. This article elaborates on the advantages and disadvantages of the animal models of acute, progressive, chronic fluctuant, malignant, and reducible obstructive jaundice, as well as their application in clinical practice. These animal models have certain limitations in reflecting the development and progression of target disease. Most animal models are established by surgery or external physical and chemical damage, and there are still no mouse models of gene knockout or overexpression. Future research will focus on the stable animal models of chronic and progressive obstructive jaundice and special types of obstructive jaundice.
- jaundice, obstructive /
- model, animal /
- reviews

HTML全文

参考文献(21)

[1]ASSIMAKOPOULOS SF, VAGIANOS CE.Bile duct ligation in rats:a reliable model of hepatorenal syndrome[J].World J Gastroenterol, 2009, 15 (1) :121-123.

[2]WEN N, ZHU YX, LYU RG, et al.Expression and significance of UCP-2 in rats with obstructive jaundice and bile flow restoration[J].J Clin Hepatol, 2015, 31 (1) :88-92. (in Chinese) 温暖, 朱以祥, 吕仁更, 等.肝组织解偶联蛋白2在梗阻性黄疸及胆道再通实验大鼠模型中的表达及意义[J].临床肝胆病杂志, 2015, 31 (1) :88-92.

[3]LIU XY, LIU RX, CUI LJ, et al.Comparison of hepatic fibrosis models and associated hepatic fibronectin expression in Wistar rats treated by bile duct ligation and CCl4[J].J Clin Hepatol, 2015, 31 (2) :219-224. (in Chinese) 刘晓亚, 刘瑞霞, 催立建, 等.胆管结扎和四氯化碳诱导Wistar大鼠肝纤维化模型的建立及相关指标的对比分析[J].临床肝胆病杂志, 2015, 31 (2) :219-224.

[4]CHEN L, FU Q, TANG Q, et al.Change of hepatic natural killer cells in mice models with obstructive jaundice and its significance[J].J Chin Pract Diagn Ther, 2016, 30 (1) :27-30. (in Chinese) 陈琳, 付强, 唐强, 等.梗阻性黄疸模型小鼠肝脏自然杀伤细胞水平变化及意义[J].中华实用诊断与治疗杂志, 2016, 30 (1) :27-30.

[5]YANG J, HUANG XB, ZHAN WP, et al.Toll-like receptor 4 expression in the repairing process of bile duct injury and its signifi cance[J].Chin J Gen Surg, 2017, 26 (2) :179-184. (in Chinese) 杨婧, 黄显斌, 詹渭鹏, 等.Toll样受体4在胆道损伤修复过程中的表达及意义[J].中国普通外科杂志, 2017, 26 (2) :179-184.

[6]SUN ZP, JIANG B, YI WM, et al.Effects of internal and external biliary drainage on liver function and regeneration after hepatectomy in rats with biliary tract obstruction[J].Chin J Gen Surg, 2016, 25 (7) :1035-1042. (in Chinese) 孙增鹏, 蒋波, 易为民, 等.胆道梗阻大鼠肝切除术后胆汁内引流和外引流对肝功能及肝再生的影响[J].中国普通外科杂志, 2016, 25 (7) :1035-1042.

[7]LI C, WANG DL, LIU L.External drainage of obstructive jaundice rat intestinal tight connection and the influence of water channel protein 8 expression[J].Clin J Med Offic, 2016, 44 (11) :1163-1166. (in Chinese) 李川, 王丹蕾, 刘璐.胆汁外引流对梗阻性黄疸大鼠肠紧密连接与水通道蛋白8表达影响[J].临床军医杂志, 2016, 44 (11) :1163-1166.

[8]XU XG, SHI CX, TANG KL, et al.Changes of function of sphincter of Oddi after short-term partial bile duct obstruction[J].Chin J Gen Surg, 2015, 24 (2) :221-225. (in Chinese) 徐贤刚, 石承先, 汤可立, 等.豚鼠不全性胆道梗阻早期Oddi括约肌功能的变化[J].中国普通外科杂志, 2015, 24 (2) :221-225.

[9]SONG N, XIA YJ, WANG X, et al.Effect of Triamcinolone-eluting biodegradable stent in leporine bile duct after injury[J].Chin JLab Diagn, 2017, 21 (2) :285-289. (in Chinese) 宋楠, 夏医君, 王烯, 等.曲安奈德药物涂层可降解支架在兔胆管损伤动物模型的研究[J].中国实验诊断学, 2017, 21 (2) :285-289.

[10]MA LF, KANG JS, LI T, et al.A novel biodegradable scaffold:biological properties and application in bile duct repair[J].Chin JTissue Eng Res, 2016, 20 (30) :4434-4441. (in Chinese) 马利锋, 康建省, 李涛, 等.新型生物可降解支架材料生物特性及在损伤胆道修复中的应用[J].中国组织工程研究, 2016, 20 (30) :4434-4441.

[11]WANG XX.The mechanism of IL-17-producing regulatory Tcells promoted bile duct inflammation in murine biliary atresia[D].Wuhan:Huazhong University of Science and Technology, 2015. (in Chinese) 王新星.炎性Treg细胞在小鼠胆道闭锁胆管炎症中的作用及机制的研究[D].武汉:华中科技大学, 2015.

[12]YU SP, LI J, HOU BZ, et al.Evaluation of rat models of acute and chronic obstructive jaundice[J].World Chin J Dig, 2011, 19 (12) :1285-1289. (in Chinese) 余水平, 李坚, 侯冰宗, 等.急慢性大鼠梗阻性黄疸模型的建立[J].世界华人消化杂志, 2011, 19 (12) :1285-1289.

[13]YU SP, LI J, GUAN XD, et al.Expression and significance of Ox-LDL in chronic obstructive jaundice rat mode[J/CD].Chin Arch Gen Surg:Electronic Edition, 2012, 6 (2) :151-156. (in Chinese) 余水平, 李坚, 关晓东, 等.氧化低密度脂蛋白在慢性梗阻性黄疸大鼠肝脏中的表达与意义[J/CD].中华普通外科学文献:电子版, 2012, 6 (2) :151-156.

[14]YU SP, ZHOU XL.Treatment with rosuvastatin calcium improves liver fibrosis in a rat model of chronic obstructive jaundice[J].World Chin J Dig, 2012, 20 (35) :3564-3569. (in Chinese) 余水平, 周雪玲.瑞舒伐他汀钙对慢性梗阻性黄疸大鼠肝脏纤维化的影响[J].世界华人消化杂志, 2012, 20 (35) :3564-3569.

[15]WANG JP, ZHANG MY, LI B, et al.Farnesyl X receptor expression in rat bile duct cancer[J].World Chin J Dig, 2015, 23 (32) :5201-5206. (in Chinese) 王洁萍, 张孟瑜, 李波, 等.FXR在胆管癌大鼠胆管组织中的表达状况[J].世界华人消化杂志, 2015, 23 (32) :5201-5206.

[16]WANG JP, ZHANG MY, Li B, et al.Ntcp expression in bile duct cancer tissues in rats[J].World Chin J Dig, 2015, 23 (29) :4694-4699. (in Chinese) 王洁萍, 张孟瑜, 李波, 等.Ntcp在胆管癌大鼠胆管肿瘤组织中的表达状况[J].世界华人消化杂志, 2015, 23 (29) :4694-4699.

[17]YU WL, FANG WZ, XU DY, et al.Establishment of a nude mouse model of human hilar cholangiocarcinoma nerve infiltration[J].Acad J Second Milit Med Univ, 2015, 36 (12) :1379-1381. (in Chinese) 俞文隆, 房文铮, 徐冬云, 等.肝门部胆管癌神经侵犯裸鼠动物模型的建立[J].第二军医大学学报, 2015, 36 (12) :1379-1381.

[18]ZHOU CX, XU DF, CHEN Z.Establishment of a novel reversible rabbit model of obstructive jaundice[J].J Nantong Univ:Medical Sciences, 2014, 34 (4) :267-270. (in Chinese) 周春献, 徐东风, 陈钟.一种新的可逆型梗阻性黄疸兔模型的建立[J].南通大学学报:医学版, 2014, 34 (4) :267-270.

[19]FANG H, CHEN QP, ZHANG XY, et al.Establishment and evaluation of a rat model of reversible obstructive jaundice[J].World Chin J Dig, 2015, 23 (25) :4015-4023. (in Chinese) 方辉, 陈强谱, 张兴元, 等.可复性梗阻性黄疸大鼠模型的建立与评价[J].世界华人消化杂志, 2015, 23 (25) :4015-4023.

[20]KAHRAMANSOY N, ERKOL H, YILMAZ EE, et al.A new model of reversible obstructive jaundice using rapidly absorbable suture materials[J].Clin Invest Med, 2012, 35 (6) :351-357.

[21]KIRKLAND JG, GODFREY CB, GARRETT R, et al.Reversible surgical model of biliary inflammation and obstructive jaundice in mice[J].J Surg Res, 2010, 164 (2) :221-227.

施引文献

资源附件(0)

访问统计