中性粒细胞与淋巴细胞比值对肝癌预后影响的Meta分析

刘健; 高驰丹; 张立鑫; 权刚; 张雨顺; 李敬东

doi:10.3969/j.issn.1001-5256.2017.07.020

中性粒细胞与淋巴细胞比值对肝癌预后影响的Meta分析

DOI: 10.3969/j.issn.1001-5256.2017.07.020

1. 四川省南充市川北医学院肝胆一科
2. 四川省南充市川北医学院病理科

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中图分类号: R735.7
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出版历程
- 收稿日期: 2017-02-04
- 出版日期: 2017-07-20

Influence of neutrophil-lymphocyte ratio on prognosis of liver cancer:a meta-analysis

First Department of Hepatobiliary Surgery, The Affiliated Hospital of North Sichuan Medical College

摘要

摘要: 目的探讨中性粒细胞与淋巴细胞比值(NLR)与肝癌患者预后的关系。方法检索Pub Med、Embase、Cochrane Library、中国生物医学文献数据库、维普、万方等数据库建库至2016年10月公开发表的关于NLR与肝癌预后关系研究的中英文文献,筛选后的文献数据用Review Manager 5.3软件进行统计分析,发表性偏倚采用漏斗图进行分析评价。结果纳入12项符合标准的研究,共计3325例肝癌患者。Meta分析结果显示,NLR升高的肝癌患者,其总体生存期[风险比(HR)=1.56,95%可信区间(95%CI):1.46~1.66,P<0.001]、无病生存期(HR=1.57,95%CI:1.23~2.00,P<0.001)和无复发生存期(HR=1.54,95%CI:1.36~1.74,P<0.001)明显缩矩。结论 NLR升高的肝癌患者预后较差,临床上应重视NLR指标,使肝癌患者及时得到预后评估和合理治疗。
- 肝肿瘤 /
- 中性白细胞 /
- 淋巴细胞 /
- 预后 /
- Meta分析
Abstract: Objective To investigate the association between neutrophil-lymphocyte ratio (NLR) and prognosis of liver cancer.Methods Pub Med, Embase and Cochrane Library, CBM, VIP, Wanfang Data were searched for Chinese and English articles on the association between NLR and prognosis of liver cancer published up to October 2016.Review Manager 5.3 was used for statistical analysis of data in these articles, and funnel plots were used to evaluate publication bias.Results A total of 12 studies which met the inclusion criteria were included, with 3325 liver cancer patients in total.The meta-analysis showed that liver cancer patients with an increased NLR had significant reductions in overall survival time (hazard ratio [HR]=1.56, 95% confidence interval [95% CI]:1.46-1.66, P<0.001) , disease-free survival (HR=1.57, 95% CI:1.23-2.00, P<0.001) , and recurrence-free survival (HR=1.54, 95% CI:1.36-1.74, P<0.001) .Conclusion Liver cancer patients with an increased NLR tend to have poor prognosis, and NLR should be taken seriously in clinical practice to provide timely prognostic evaluation and rational treatment for liver cancer patients.
- liver neoplasms /
- neutrophils /
- lymphocytes /
- prognosis /
- Meta-analysis

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参考文献(24)

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