直接抗病毒药物联合PR方案（PEG-IFN联合利巴韦林）在丙型肝炎抗病毒治疗新时代的价值

陈新月; 柳雅立; 任姗

doi:10.3969/j.issn.1001-5256.2017.06.009

直接抗病毒药物联合PR方案（PEG-IFN联合利巴韦林）在丙型肝炎抗病毒治疗新时代的价值

DOI: 10.3969/j.issn.1001-5256.2017.06.009

首都医科大学附属北京佑安医院

基金项目:

首都临床特色应用研究(Z151100004015181,Z161100000516018)；首都卫生发展科研重点专项(首发2016-1-218-3)；

详细信息

中图分类号: R512.63
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出版历程
- 出版日期: 2017-06-20

Value of direct-acting antivirals combined with PR regimen (PEG-IFN combined with ribavirin) in the new era of antiviral therapy for hepatitis C

Research funding:

摘要

摘要: PEG-IFN联合利巴韦林（PR方案）在中国已有10多年的使用经验,随着直接抗病毒药物（DAA）的发展,丙型肝炎治疗方案出现多元化。DAA联合PR方案,在保留IFN有利慢性丙型肝炎（CHC）患者长期预后等优势的前提下使用DAA,可提高疗效、缩短疗程,进一步改善CHC的治疗现状。介绍PR、DAA联合PR及DAA全口服方案的优劣,旨在探讨更适合不同CHC患者的治疗方案,为临床实践提供参考。
- 肝炎,丙型,慢性 /
- 抗病毒药 /
- 治疗
Abstract: Pegylated interferon (PEG-IFN) combined with ribavirin (PR regimen) has been used in China for more than 10 years. With the development of direct-acting antiviral agents (DAAs) , the therapeutic regimens for hepatitis C has become more and more diverse. In the regimen of DAAs combined with PR regimen, IFN helps to benefit the long-term prognosis of patients with chronic hepatitis C (CHC) , and the addition of DAAs may improve therapeutic effect, shorten the course of treatment, and further improve the current status of treatment of CHC. This article introduces the advantages and disadvantages of PR regimen, DAAs combined with PR regimen, and oral regimen with DAAs, in order to investigate the therapeutic regimens suitable for different CHC patients and provide a reference for clinical practice.
- hepatitis C, chronic /
- antiviral agents /
- therapy

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