肝纤维化相关信号转导通路研究进展

彭琴; 赵绅君; 李武

doi:10.3969/j.issn.1001-5256.2017.05.035

肝纤维化相关信号转导通路研究进展

DOI: 10.3969/j.issn.1001-5256.2017.05.035

昆明医科大学第一附属医院感染科

基金项目:

云南省自然科学基金(2009CD087)；

详细信息

中图分类号: R575.2
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- 被引次数: 0
出版历程
- 收稿日期: 2016-11-14
- 出版日期: 2017-05-20

Research advances in signaling pathways involved in the development of hepatic fibrosis

Department of Infectious Diseases, The First Affiliated Hospital of Kunming Medical University

Research funding:

摘要

摘要: 肝纤维化是肝脏对各种慢性肝损伤进行自我修复的一种病理过程,最终进展为肝硬化、肝衰竭,甚至肝癌。如何早期干预和治疗肝纤维化显得尤为重要。总结了TGFβ/Smad信号通路、Notch信号通路、Wnt信号通路、Hedgehog信号通路及整合素信号通路在肝纤维化发生机制中的最新研究进展,指出各信号通路在肝纤维化的发生发展中发挥极其重要的作用,有望为肝纤维化的治疗提供新的方向。
- 肝硬化 /
- 信号传导 /
- 肝星状细胞 /
- 综述
Abstract: Liver fibrosis is a pathological process for the liver to repair various chronic liver injuries and may eventually progress to liver cirrhosis, liver failure, or even liver cancer.Therefore, early intervention and treatment of liver fibrosis is of particular importance.This article summarizes the latest research advances in the roles of TGF-β/Smad signaling pathway, Notch signaling pathway, Wnt signaling pathway, Hedgehog signaling pathway, and integrin signaling pathway in the pathogenesis of liver fibrosis and points out that these signaling pathways play an extremely important role in the development and progression of liver fibrosis and may provide new directions for the treatment of liver fibrosis
- liver cirrhosis /
- signal transduction /
- hepatic stellate cells /
- review

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参考文献(41)

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