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Research advances in MRI features and diagnosis of hepatocellular adenomas
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摘要:
肝腺瘤（HCA）是一种少见的肝脏良性肿瘤,依据分子遗传学及病理学的不同,分为4种不类同型:炎症型（IHCA）、肝细胞核因子1α突变型（H-HCA）、β-连环蛋白突变型（β-HCA）和未分类型,其发生率分别为40%50%、30%40%、10%15%、10%。在各类型HCA中,β-HCA有高风险出血及恶性转化的可能,而H-HCA几乎不会恶性转化,因此对各类型HCA准确的诊断就显得尤为重要。介绍了各类型HCA常规磁共振成像（MRI）及肝细胞靶向造影剂增强扫描的影像学特征,并与肝脏其他实性肿瘤如肝局灶性结节性增生、大结节性再生性增生、非肝硬化患者肝癌和纤维板层型肝癌进行比较。认为MRI及肝细胞靶向造影剂在各类型HCA的诊断及鉴别中有不可替代的作用。
Abstract:Hepatocellular adenomas( HCA) are rare benign tumors of the liver,and according to the differences in molecular genetics and pathology,HCA is categorized as inflammatory hepatocellular adenoma( IHCA),HCA with hepatocyte nuclear factor 1-alpha mutation( H-HCA),HCA with β-catenin mutation( β-HCA),and an undefined type. The incidence of these four types is 40%-50%,30%-40%,10%-15%,and 10%,respectively. In these four types of HCA,β-HCA has high risk of bleeding and malignant transformation,while H-HCA is not likely to show malignant transformation. Therefore,the accurate diagnosis of these types of HCA is very important. This article introduces the radiological features of these types of HCA on conventional MRI and hepatocyte-targeted contrast-enhanced scan and compares these findings with other types of liver solid tumors such as focal nodular hyperplasia,nodular regenerative hyperplasia,liver cancer in non-cirrhotic patients,and fibrolamellar carcinoma of the liver. It is pointed out that MRI and hepatocyte-targeted contrast agents play an important role in the diagnosis and differentiation of HCA.
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Key words:
- adenoma /
- liver cell /
- magnetic resonance imaging /
- diagnosis
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