调节性T淋巴细胞和辅助性T淋巴细胞17在HBV相关肝病中的作用

周燕; 经翔; 朱争艳

doi:10.3969/j.issn.1001-5256.2016.10.040

调节性T淋巴细胞和辅助性T淋巴细胞17在HBV相关肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2016.10.040

1. 天津医科大学第三中心临床学院
2. 天津市第三中心医院超声科
3. 天津市人工细胞重点实验室天津市肝胆疾病研究所

基金项目:

天津市卫生局公关基金资助(13KG111)；

详细信息

中图分类号: R512.62
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- 被引次数: 0
出版历程
- 出版日期: 2016-10-20

Roles of regulatory T cells and T-helper cells in hepatitis B virus-related liver diseases

The Third Central Clinical College, Tianjin Medical University

Research funding:

摘要

摘要:
目前,免疫细胞在HBV感染免疫调节中的作用得到广泛关注。对近年来调节性T淋巴细胞(Treg)和辅助性T淋巴细胞(Th)17在HBV相关性疾病,尤其是HBV相关性肝纤维化和肝衰竭以及肝细胞癌的发生、发展和预后中所起的作用进行了回顾。指出了Treg和Th17在HBV感染不同时期的动态变化及其在肝细胞癌中的作用还需要进一步研究,并期待后期研究通过不同信号通路对Treg或Th17进行调节,为HBV相关疾病治疗提供更加精准的方向。
- 肝炎病毒,乙型 /
- T淋巴细胞,调节性 /
- T淋巴细胞,辅助诱导 /
- 综述
Abstract:
In recent years,the role of immune cells in hepatitis B virus( HBV)-related liver diseases has attracted more and more attention. This article reviews the roles of regulatory T cells( Treg) and T-helper cell type 17( Th17) in the development,progression,and prognosis of HBV-related liver diseases,especially HBV-related liver fibrosis and liver failure,as well as hepatocellular carcinoma. It is pointed out that the dynamic changes of Treg and Th17 cells in different stages of HBV infection and their roles in hepatocellular carcinoma need further investigation,and future studies on the regulatory effects of various signaling pathways on Treg or Th17 cells are needed to provide a more precise direction for the treatment of HBV-related diseases.
- hepatitis B virus /
- T-lymphocytes /
- regulatory /
- T-lymphocytes

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参考文献(49)

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