慢性HBV/HCV感染人群伴随的免疫相关表现

刘佩浩; 饶慧瑛

doi:10.3969/j.issn.1001-5256.2016.10.009

慢性HBV/HCV感染人群伴随的免疫相关表现

DOI: 10.3969/j.issn.1001-5256.2016.10.009

北京大学人民医院，北京大学肝病研究所

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中图分类号: R512.6
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出版历程
- 出版日期: 2016-10-20

Related immune manifestations in patients with chronic hepatitis B virus and chronic hepatitis C virus infection

Peking University People′s Hospital & Peking University Hepatology Institute

摘要

摘要:
慢性HBV/HCV感染者常常伴有自身免疫系统紊乱,在丙型肝炎中尤为常见。介绍了慢性丙型肝炎患者免疫状态紊乱的机制,出现非器官特异性自身抗体的比例,以及伴随的免疫相关疾病,如混合型冷球蛋白血症、肾小球肾炎、干燥综合征、甲状腺疾病、2型糖尿病的临床表现、诊断和治疗等。简述了慢性乙型肝炎患者免疫状态紊乱的机制、相关的免疫表现以及抗病毒治疗对其的影响。慢性乙型或丙型肝炎的抗病毒治疗可以减轻伴随的免疫系统疾病,但是不宜采用干扰素治疗,因此,乙型肝炎患者应采用核苷和核苷酸类药物治疗,丙型肝炎患者应采用直接抗病毒药物治疗。
- 肝炎病毒,乙型 /
- 肝炎病毒属 /
- 自身免疫疾病
Abstract:
Patients with chronic hepatitis B virus( HBV) and hepatitis C virus( HCV) infection are frequently complicated by autoimmune disorders,which is commonly seen in patients with hepatitis C. This article introduces the mechanism of immune disorders in patients with chronic hepatitis C,the proportion of patients with non-organ specific autoantibody,and the clinical manifestations,diagnosis,and treatment of related immune diseases,such as mixed cryoglobulinemia,glomerulonephritis,Sjogren's syndrome,thyroid disease,and type 2 diabetes,as well as the mechanism of immune disorders,related immune manifestations,and effect of antiviral therapy in patients with chronic hepatitis B. Antiviral therapy for chronic hepatitis B and C can alleviate related immune diseases,but interferon therapy is not appropriate.Therefore,the patients with hepatitis B should be treated with nucleos( t) ide analogues,while those with hepatitis C should be treated with direct-acting antiviral agents.
- hepatitis B virus /
- hepacivirus /
- autoimmune diseases

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参考文献(25)

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