肿瘤相关巨噬细胞在原发性肝癌发生发展中的作用

陈伟; 周赟; 龚建平

doi:10.3969/j.issn.1001-5256.2016.07.048

肿瘤相关巨噬细胞在原发性肝癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2016.07.048

1. 重庆渝北区中医院肝胆外科
2. 重庆医科大学附属第二医院肝胆外科

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2016-07-20

Role of tumor-associated macrophages in development and progression of primary liver cancer

摘要

摘要: 近年来,炎症反应与肿瘤的关系受到了广泛关注。肿瘤相关巨噬细胞(TAM)对肿瘤的生长增殖、代谢转移等都具有重要作用,许多研究表明TAM多为M2表型,已经证实其在原发性肝癌中具有促进肿瘤生长、代谢、转移及血管生成等作用。通过促M2型巨噬细胞向M1型转化,改变了肝癌细胞的一些生物学表现,这也许可能成为一种新的肝癌治疗策略。就近年来TAM与原发性肝癌进展的相关性研究进展及可能的治疗方案作一概述。
- 肝肿瘤 /
- 巨噬细胞 /
- 综述
Abstract: The relationship between inflammatory response and tumor has gained great attention in recent years. Tumor- associated macrophages( TAMs) play an important role in tumor growth,proliferation,metabolism,and metastasis. Many studies have confirmed that most TAMs have an M2 phenotype and can promote tumor growth,metabolism,metastasis,and angiogenesis in primary liver cancer. The transformation of M2 macrophages into M1 macrophages changes the biological manifestations of hepatoma cells,which may become a new therapeutic strategy for liver cancer. This article reviews the research advances in the association between TAMs and the progression of primary liver cancer,as well as possible therapeutic regimens.
- liver neoplasms /
- macrophages /
- review

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参考文献(20)

[1]YAN W,LIU X,MA H,et al.Tim-3 fosters HCC developmen by enhancing TGF-β-mediated alternative activation of macrophages[J].Gut,2015,64(10):1593-1604.

[2]DOWNEY CM,AGHAEI M,SCHWENDENER RA,et al.DMXAAcauses tumor site-specific vascular disruption in murine non-smal cell lung cancer,and like the endogenous non-canonical cyclic dinucleotide STING agonist,2'3'-cG AMP,induces M2 macrophage repolarization[J].PLoS One,2014,9(6):e99988.

[3]KONG LQ,ZHU XD,XU HX,et al.The clinical significance o the CD163+and CD68+macrophages in patients with hepatocellular carcinoma[J].PLoS One,2013,8(3):e59771.

[4]KAZANKOV K,RODE A,SIMONSEN K,et al.Macrophage activation marker soluble CD163 may predict disease progression in hepatocellular carcinoma[J].Scand J Clin Lab Invest,2016,76(1):64-73.

[5]EHLING J,TACKE F.Role of chemokine pathways in hepatobiliary cancer[J].Cancer Lett,2015.pii:S0304-3835(15)00411-5.

[6]SEKI E,DE MINICIS S,GWAK GY,et al.CCR1 and CCR5 promote hepatic fibrosis in mice[J].J Clin Invest,2009,119(7):1858-1870.

[7]BARASHI N,WEISS ID,WALD O,et al.Inflammation-induced hepatocellular carcinoma is dependent on CCR5 in mice[J].Hepatology,2013,58(3):1021-1030.

[8]WAN S,KUO N,KRYCZEK I,et al.Myeloid cells in hepatocellular carcinoma[J].Hepatology,2015,62(4):1304-1312.

[9]RODERFELD M,RATH T,LAMMERT F,et al.Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC[J].World J Hepatol,2010,2(5):175-179.

[10]WU J,ZHANG J,SHEN B,et al.Long noncoding RNA lncT CF7,induced by IL-6/STAT3 transactivation,promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition[J].J Exp Clin Cancer Res,2015,34(1):116.

[11]QIAN BZ,POLLARD JW.Macrophage diversity enhances tumor progression and metastasis[J].Cell,2010,141(1):39-51.

[12]HE G,KARIN M.NF-κB and STAT3-key players in liver inflammation and cancer[J].Cell Res,2011,21(1):159-168.

[13]BUPATHI M,KASEB A,MERIC-BERNSTAM F,et al.Hepatocellular carcinoma:where there is unmet need[J].Mol Oncol,2015,9(8):1501-1509.

[14]LUO D,WANG Z,WU J,et al.The role of hypoxia inducible factor-1 in hepatocellular carcinoma[J].Biomed Res Int,2014,2014(3-4):409272.

[15]BURKE B,TANG N,CORKE KP,et al.Expression of HIF-1alpha by human macrophages:implications for the use of macrophages in hypoxia-regulated cancer gene therapy[J].J Pathol,2002,196(2):204-212.

[16]ZHU XD,ZHANG JB,ZHUANG PY,et al.High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma[J].J Clin Oncol,2008,26(16):2707-2716.

[17]CAPECE D,FISCHIETTI M,VERZELLA D,et al.The inflammatory microenvironment in hepatocellular carcinoma:a pivotal role for tumor-associated macrophages[J].Biomed Res Int,2013,2013(1):187204.

[18]MAO Y,WANG B,XU X,et al.Glycyrrhizic acid promotes M1macrophage polarization in murine bone marrow-derived macrophages associated with the activation of JNK and NF-κB[J].Mediators Inflamm,2015,2015:372931.

[19]TOSELLO-TRAMPONT AC,KRUEGER P,NARAYANAN S,et al.NKp46+natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice[J].Hepatology,2016,63(3):799-812.

[20]FAROOQUE A,AFRIN F,ADHIKARI JS,et al.Polarization of macrophages towards M1 phenotype by a combination of 2-deoxyd-glucose and radiation:implications for tumor therapy[J].Immunobiology,2016,221(2):269-281.

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