HBV前S/S区变异与HBV相关肝病的关系

姚明琦; 陈杰; 张晶

doi:10.3969/j.issn.1001-5256.2016.07.044

HBV前S/S区变异与HBV相关肝病的关系

DOI: 10.3969/j.issn.1001-5256.2016.07.044

1. 山西省运城市第二医院肝病二科
2. 首都医科大学附属北京佑安医院丙肝与中毒性肝病科

基金项目:

北京市科委首都市民健康项目培育(Z141100002114022)；北京市重点实验室项目(2014GZBH01)；

详细信息

中图分类号: R512.62;R575
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- 文章访问数: 234
- HTML全文浏览量: 12
- PDF下载量: 57
- 被引次数: 0
出版历程
- 出版日期: 2016-07-20

Association between hepatitis B virus pre-S/S gene variants and HBV-related liver diseases

Research funding:

摘要

摘要: HBV前S（pre-S）/S区基因变异导致了多种相关的病理及临床后果,包括隐匿性乙型肝炎、暴发性肝炎或肝衰竭、HBs Ag/抗-HBs双阳性的HBV感染、原发性肝癌,其参与了这些HBV相关疾病的发生发展。介绍了HBV pre-S/S基因组变异与这些HBV相关性疾病发生发展的关系,对相关临床及基础研究的结果作一综述,并强调了目前研究中尚存在争议的问题,为其进一步研究提供线索。
- 肝炎病毒,乙型 /
- 肝炎表面抗原,乙型 /
- 突变 /
- 肝疾病 /
- 综述
Abstract: The pre- S/S gene variants of hepatitis B virus( HBV) cause various pathological and clinical outcomes. Occult hepatitis B,fulminant hepatitis or liver failure,HBs Ag- and HBs Ab- positive HBV infection,and primary liver cancer are all associated with HBV pre- S/S gene variants,which are involved in the development and progression of these HBV- related diseases. This article introduces the association between HBV pre- S/S gene variants and the development and progression of HBV- related liver diseases,reviews the results of related clinical and basic research,and emphasizes the controversial issues in current research,in order to provide clues for further studies.
- hepatitis B virus /
- hepatitis B surface antigens /
- mutation /
- liver diseases /
- review

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参考文献(29)

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