Abstract: Objective To investigate the traditional Chinese herbs and core prescriptions commonly used by Professor Qian Ying in the syndrome differentiation- based treatment of primary liver cancer,and to guide clinical medication. Methods A retrospective analysis was performed for the clinical data of the patients diagnosed and treated by Professor Qian Ying. A descriptive analysis was performed to analyze Professor Qian Ying's clinical medication and prescriptions in the treatment of primary liver cancer,and the complex network and clustering with point mutual information were used to analyze the complex association between multiple traditional Chinese herbs. Results A total of111 patients with primary liver cancer were enrolled. There were 287 visits,287 prescriptions,and 132 traditional Chinese herbs in total.The core herbs used by Professor Qian Ying were Visci herba,raw Astragalus membranaceus,Salvia miltiorrhiza,Oldenlandia diffusa,and Polygoni Orientalis Fructus,and this result was consistent with the composition of Huqi powder developed by Professor Qian Ying. The prescriptions commonly used included Huqi powder,Shengmai decoction,and Xiaoyao powder. Conclusion Salvia miltiorrhiza is the special herb used by Professor Qian Ying in the treatment of primary liver cancer and Huqi powder developed by Professor Qian Ying is the commonly used prescription.