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血浆血管性血友病因子裂解酶在肝脏疾病发病机制和诊断中的作用

许姗姗 陈亚利 张晶

许姗姗, 陈亚利, 张晶. 血浆血管性血友病因子裂解酶在肝脏疾病发病机制和诊断中的作用[J]. 临床肝胆病杂志, 2016, 32(2): 390-392. DOI: 10.3969/j.issn.1001-5256.2016.02.043
引用本文: 许姗姗, 陈亚利, 张晶. 血浆血管性血友病因子裂解酶在肝脏疾病发病机制和诊断中的作用[J]. 临床肝胆病杂志, 2016, 32(2): 390-392. DOI: 10.3969/j.issn.1001-5256.2016.02.043
Xu ShanShan, Chen YaLi, Zhang Jing. Role of ADAMTS13 in diagnosis and pathogenesis of liver diseases[J]. J Clin Hepatol, 2016, 32(2): 390-392. DOI: 10.3969/j.issn.1001-5256.2016.02.043
Citation: Xu ShanShan, Chen YaLi, Zhang Jing. Role of ADAMTS13 in diagnosis and pathogenesis of liver diseases[J]. J Clin Hepatol, 2016, 32(2): 390-392. DOI: 10.3969/j.issn.1001-5256.2016.02.043

血浆血管性血友病因子裂解酶在肝脏疾病发病机制和诊断中的作用

DOI: 10.3969/j.issn.1001-5256.2016.02.043
详细信息
  • 中图分类号: R575

Role of ADAMTS13 in diagnosis and pathogenesis of liver diseases

  • 摘要: 近期研究表明机体凝血功能和肝脏微循环障碍在肝脏疾病的发生、发展过程中起着重要作用。ADAMTS13又称血管性血友病因子裂解酶,是由肝星状细胞产生的金属蛋白酶,主要功能是裂解血管内皮细胞产生的血管性血友病因子多聚体,从而调节血小板粘附能力,进而影响机体的凝血功能和微循环。回顾ADAMTS13在多种重症肝病如肝硬化、重症酒精性肝炎、干细胞移植后肝静脉阻塞病和移植肝功能障碍等病理生理过程中发挥的重要作用,阐述了其与肝脏疾病严重程度的关系,认为血浆ADAMTS13参与了多种肝脏疾病的发生、发展过程,通过检测其水平和活性有助于肝脏疾病的诊断及鉴别诊断。

     

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  • 收稿日期:  2015-06-18
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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