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急性胰腺炎患者血清M30、M65及白细胞介素17水平的变化及意义

郝婷婷 马晓鹏 温彦丽 戴光荣 冯义朝 张莉

郝婷婷, 马晓鹏, 温彦丽, 戴光荣, 冯义朝, 张莉. 急性胰腺炎患者血清M30、M65及白细胞介素17水平的变化及意义[J]. 临床肝胆病杂志, 2016, 32(2): 329-332. DOI: 10.3969/j.issn.1001-5256.2016.02.027
引用本文: 郝婷婷, 马晓鹏, 温彦丽, 戴光荣, 冯义朝, 张莉. 急性胰腺炎患者血清M30、M65及白细胞介素17水平的变化及意义[J]. 临床肝胆病杂志, 2016, 32(2): 329-332. DOI: 10.3969/j.issn.1001-5256.2016.02.027
Hao TingTing, Ma XiaoPeng, Wen YanLi, Dai GuangRong, Feng YiChao, Zhang Li. Changes in serum levels of M30,M65,and IL-17 and their clinical significance in patients with acute pancreatitis[J]. J Clin Hepatol, 2016, 32(2): 329-332. DOI: 10.3969/j.issn.1001-5256.2016.02.027
Citation: Hao TingTing, Ma XiaoPeng, Wen YanLi, Dai GuangRong, Feng YiChao, Zhang Li. Changes in serum levels of M30,M65,and IL-17 and their clinical significance in patients with acute pancreatitis[J]. J Clin Hepatol, 2016, 32(2): 329-332. DOI: 10.3969/j.issn.1001-5256.2016.02.027

急性胰腺炎患者血清M30、M65及白细胞介素17水平的变化及意义

DOI: 10.3969/j.issn.1001-5256.2016.02.027
详细信息
  • 中图分类号: R576

Changes in serum levels of M30,M65,and IL-17 and their clinical significance in patients with acute pancreatitis

  • 摘要: 目的探讨急性胰腺炎(AP)患者血清M30、M65及IL-17水平的变化及临床意义。方法选取2009年12月-2013年12月延安大学附属医院收治的126例AP患者,根据临床诊断分为轻度急性胰腺炎(82例)和急性重症胰腺炎(44例)。选择同期本院体检中心体检的健康人员107例为对照组,分别于第1、2、4天分析3组患者血清中M30、M65、白细胞介素(IL)17水平,以及血清M30/M65值。计量资料多组间比较采用方差分析,进一步两两比较采用SNK-q检验,两组间比较采用独立样本t检验;计数资料组间比较采用χ2检验。结果急性重症胰腺炎及轻度急性胰腺炎患者在第1、2、4天时其血清M30、M65、IL-17水平均显著高于健康受试者(P值均<0.05),而M30/M65比值则显著低于健康受试者(P<0.001);急性重症胰腺炎患者在第1、2、4天时其血清M30、M65水平均显著高于轻度急性胰腺炎患者(P值均<0.001),急性重症胰腺炎患者的M30/M65值则在第1天时显著低于轻度胰腺炎患者(P值均<0.001),但IL-17在轻度急性胰腺炎患者与急性重症胰腺炎患者间差异...

     

  • [1]BANKS PA,FREEMAN ML.Practice guidelines in acute pancreatitis[J].Am J Gastroenterol,2006,101(10):2379-2400.
    [2]PONGPRASOBCHAI S,JIANJAROONWONG V,CHARATCHAROENWITTHAYA P,et al.Erythrocyte sedimentation rate and C-reactive protein for the prediction of severity of acute pancreatitis[J].Pancreas,2010,39(8):1226-1230.
    [3]GUKOVSKAYA AS,PANDOL SJ.Cell death pathways in pancreatitis and pancreatic cancer[J].Pancreatology,2004,4(6):567-586.
    [4]NUEZ G,BENEDICT MA,HU Y,et al.Caspases:the proteases of the apoptotic pathway[J].Oncogene,1998,17(25):3237-3245.
    [5]CAULIN C,SALVESEN GS,OSHIMA RG.Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis[J].J Cell Biol,1997,138(6):1379-1394.
    [6]CRAIG DG,LEE P,PRYDE EA,et al.Circulating apoptotic and necrotic cell death markers in patients with acute liver injury[J].Liver Int,2011,31(8):1127-1136.
    [7]BANCHEREAU J,PASCUAL V,O'GARRA A.From IL-2 to IL-37:the expanding spectrum of anti-inflammatory cytokines[J].Nat Immunol,2012,13(10):925-931.
    [8]Pancreas Study Group,Chinese Society of Gastroenterology,Chinese Medical Association.Chinese guidelines for the management of acute pancreatitis(draft)[J].Chin J Int Med,2004,43(3):236-238.(in Chinese)中华医学会消化病学分会胰腺疾病学组.中国急性胰腺炎诊治指南(草案)[J].中华内科杂志,2004,43(3):236-238.
    [9]BANKS PA,FREEMAN ML.Pratice guidelines in acute pancreatitis[J].AM J Gastroenterol,2006,101(10):2379-2400.
    [10]BARRETO SG,RODRIGUES J.Comparison of APACHEⅡand Imrie Scoring Systems in predicting the severity of acute pancreatitis[J].World J Emerg Surg,2007,2:33.
    [11]BCHLER M,MALFERTHEINER P,SCHOETENSACK C,et al.Sensitivity of antiproteases,complement factors and C-reactive protein in detecting pancreatic necrosis.Results of a prospective clinical study[J].Int J Pancreatol,1986,1(3-4):227-235.
    [12]NEOPTOLEMOS JP,KEMPPAINEN EA,MAYER JM,et al.Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide:a multicentre study[J].Lancet,2000,355(9219):1955-1960.
    [13]SUNG KF,ODINOKOVA IV,MARENINOVA OA,et al.Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis[J].Exp Cell Res,2009,315(11):1975-1989.
    [14]SCHUTTE B,HENFLING M,KLGEN W,et al.Keratin 8/18breakdown and reorganization during apoptosis[J].Exp Cell Res,2004,297(1):11-26.
    [15]MIOSSEC P,KOLLS JK.Targeting IL-17 and TH17 cells in chronic inflammation[J].Nat Rev Drug Discov,2012,11(10):763-776.
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出版历程
  • 收稿日期:  2015-07-08
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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