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连续性血液净化治疗重症急性胰腺炎合并多器官功能障碍综合征的效果观察

张勇 曾维政 王云侠 翁敏 郑淑梅 蒋明德

张勇, 曾维政, 王云侠, 翁敏, 郑淑梅, 蒋明德. 连续性血液净化治疗重症急性胰腺炎合并多器官功能障碍综合征的效果观察[J]. 临床肝胆病杂志, 2016, 32(2): 320-323. DOI: 10.3969/j.issn.1001-5256.2016.02.025
引用本文: 张勇, 曾维政, 王云侠, 翁敏, 郑淑梅, 蒋明德. 连续性血液净化治疗重症急性胰腺炎合并多器官功能障碍综合征的效果观察[J]. 临床肝胆病杂志, 2016, 32(2): 320-323. DOI: 10.3969/j.issn.1001-5256.2016.02.025
Zhang Yong, Zeng WeiZheng, Wang YunXia, Weng Min, Zheng ShuMei, Jiang MingDe. Effect of continuous blood purification in treatment of patients with severe acute pancreatitis and multiple organ dysfunction syndrome[J]. J Clin Hepatol, 2016, 32(2): 320-323. DOI: 10.3969/j.issn.1001-5256.2016.02.025
Citation: Zhang Yong, Zeng WeiZheng, Wang YunXia, Weng Min, Zheng ShuMei, Jiang MingDe. Effect of continuous blood purification in treatment of patients with severe acute pancreatitis and multiple organ dysfunction syndrome[J]. J Clin Hepatol, 2016, 32(2): 320-323. DOI: 10.3969/j.issn.1001-5256.2016.02.025

连续性血液净化治疗重症急性胰腺炎合并多器官功能障碍综合征的效果观察

DOI: 10.3969/j.issn.1001-5256.2016.02.025
详细信息
  • 中图分类号: R576;R459.7

Effect of continuous blood purification in treatment of patients with severe acute pancreatitis and multiple organ dysfunction syndrome

  • 摘要:

    目的观察连续性血液净化(CBP)对重症急性胰腺炎(SAP)合并多器官功能障碍综合征(MODS)患者血清炎症介质的影响。方法选取2008年4月-2013年12月成都军区总医院收治的SAP合并MODS患者65例,采用非随机同期对照试验方法按治疗方式不同分为两组,其中对照组(n=33)接受内科综合治疗,治疗组(n=32)在内科综合治疗基础上给予CBP治疗。监测患者CBP治疗前后APACHEⅡ评分、MODS评分以及血清肿瘤坏死因子(TNF)α、C-反应蛋白(CRP)、血小板衍化生长因子(PAF)、白细胞介素(IL)6、IL-18、一氧化氮(NO)水平变化。计量资料组间比较采用成组t检验,同组治疗前后比较采用配对t检验;计数资料组间比较采用χ2检验。结果两组患者治疗后,APACHEⅡ、MODS评分及血清TNFα、CRP、IL-6、IL-18、PAF、NO水平均较治疗前明显降低,差异均有统计学意义(P值均<0.05),且治疗组较对照组降低更为明显(P值均<0.001);治疗组患者存活率为90.6%(29/32),对照组患者存活率为78.8%(26/33),两组存活率比较差异无统计学意义...

     

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出版历程
  • 收稿日期:  2015-07-20
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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