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脾切除术与部分脾动脉栓塞术治疗肝硬化脾功能亢进近期疗效比较的Meta分析

何海冠 沈艺南 庞书杰 杨田 卢军华

何海冠, 沈艺南, 庞书杰, 杨田, 卢军华. 脾切除术与部分脾动脉栓塞术治疗肝硬化脾功能亢进近期疗效比较的Meta分析[J]. 临床肝胆病杂志, 2016, 32(2): 301-306. DOI: 10.3969/j.issn.1001-5256.2016.02.021
引用本文: 何海冠, 沈艺南, 庞书杰, 杨田, 卢军华. 脾切除术与部分脾动脉栓塞术治疗肝硬化脾功能亢进近期疗效比较的Meta分析[J]. 临床肝胆病杂志, 2016, 32(2): 301-306. DOI: 10.3969/j.issn.1001-5256.2016.02.021
He HaiGuan, Shen YiNan, Pang ShuJie, Yang Tian, Lu JunHua. Short-term efficacy of splenectomy versus partial splenic embolization for liver cirrhosis and hypersplenism: a Meta-analysis[J]. J Clin Hepatol, 2016, 32(2): 301-306. DOI: 10.3969/j.issn.1001-5256.2016.02.021
Citation: He HaiGuan, Shen YiNan, Pang ShuJie, Yang Tian, Lu JunHua. Short-term efficacy of splenectomy versus partial splenic embolization for liver cirrhosis and hypersplenism: a Meta-analysis[J]. J Clin Hepatol, 2016, 32(2): 301-306. DOI: 10.3969/j.issn.1001-5256.2016.02.021

脾切除术与部分脾动脉栓塞术治疗肝硬化脾功能亢进近期疗效比较的Meta分析

DOI: 10.3969/j.issn.1001-5256.2016.02.021
详细信息
  • 中图分类号: R657.63

Short-term efficacy of splenectomy versus partial splenic embolization for liver cirrhosis and hypersplenism: a Meta-analysis

  • 摘要: 目的系统评价部分脾动脉栓塞术(PSE)和脾切除术治疗肝硬化脾功能亢进的疗效。方法计算机检索2005年1月1日-2015年5月30日Medline、Embase、Web of Science、中国知网、万方数据库、维普收录的评估PSE与脾切除术治疗肝硬化脾功能亢进疗效的文献,文献纳入由两位研究者独立筛选,经过质量评价与数据提取后,采用Rev Man5.3进行Meta分析。结果最终纳入10篇对照研究,共638例患者。4项研究的合并分析结果显示术后1周PSE组对外周血小板的影响明显低于脾切除术组[加权均数差(WMD)=-65.71,95%可信区间(95%CI):-120.24-11.18,P=0.02];而术后1个月两组差异无统计学意义(WMD=0.68,95%CI:-8.169.52,P=0.88);2项研究的合并分析结果显示术后1个月PSE组自然杀伤细胞的含量较脾切除术组高(WMD=6.03,95%CI:3.808.26,P<0.001),且术后1年两组差异仍有统计学意义(WMD=3.60,95%CI:1.25

     

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  • 收稿日期:  2015-07-27
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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