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肝硬化上消化道出血预防性抗感染治疗失败的影响因素

李孝楼 陈明胜 甘巧蓉 江晓燕 陈立

李孝楼, 陈明胜, 甘巧蓉, 江晓燕, 陈立. 肝硬化上消化道出血预防性抗感染治疗失败的影响因素[J]. 临床肝胆病杂志, 2016, 32(2): 288-291. DOI: 10.3969/j.issn.1001-5256.2016.02.018
引用本文: 李孝楼, 陈明胜, 甘巧蓉, 江晓燕, 陈立. 肝硬化上消化道出血预防性抗感染治疗失败的影响因素[J]. 临床肝胆病杂志, 2016, 32(2): 288-291. DOI: 10.3969/j.issn.1001-5256.2016.02.018
Li XiaoLou, Chen MingSheng, Gan QiaoRong, Jiang XiaoYan, Chen Li. Risk factors for antibiotic prophylaxis failure in patients with liver cirrhosis and upper gastrointestinal bleeding[J]. J Clin Hepatol, 2016, 32(2): 288-291. DOI: 10.3969/j.issn.1001-5256.2016.02.018
Citation: Li XiaoLou, Chen MingSheng, Gan QiaoRong, Jiang XiaoYan, Chen Li. Risk factors for antibiotic prophylaxis failure in patients with liver cirrhosis and upper gastrointestinal bleeding[J]. J Clin Hepatol, 2016, 32(2): 288-291. DOI: 10.3969/j.issn.1001-5256.2016.02.018

肝硬化上消化道出血预防性抗感染治疗失败的影响因素

DOI: 10.3969/j.issn.1001-5256.2016.02.018
详细信息
  • 中图分类号: R575.2

Risk factors for antibiotic prophylaxis failure in patients with liver cirrhosis and upper gastrointestinal bleeding

  • 摘要: 目的探讨肝硬化上消化道出血患者接受预防性抗感染治疗失败的影响因素。方法回顾性分析2011年1月-2014年6月福建医科大学孟超肝胆医院收治的肝硬化上消化道出血患者82例,所有患者均接受三代头孢菌素预防性抗感染治疗7 d,观察抗感染治疗2周内的疗效,比较分析预防有效组和无效组之间临床特征的差异,计量资料组间比较采用t检验,计数资料组间比较采用χ2检验或Wilcoxon秩和检验。应用Logistic回归分析导致预防性抗感染失败的影响因素。结果 38例(46.4%)患者发生继发感染,预防有效组和预防无效组在凝血酶原时间、入住ICU的比例、入住ICU时间、接受深静脉穿刺的比例、Child-Pugh分级和Child-Pugh评分上比较差异均有统计学意义(P值均<0.05)。Child-Pugh分级和入住ICU是预防性抗生素治疗失败的独立危险因素,比值比分别为2.455[95%可信区间(95%CI):1.015.97,P=0.048]和4.12(95%CI:1.3212.83,P=0.015)。结论三代头孢菌素预防性抗感染治疗失败率较高,入住ICU...

     

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  • 收稿日期:  2015-07-15
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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