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核苷和核苷酸类药物对慢性乙型肝炎患者肾小球滤过率和血肌酐水平的影响

徐勇 冯继红

徐勇, 冯继红. 核苷和核苷酸类药物对慢性乙型肝炎患者肾小球滤过率和血肌酐水平的影响[J]. 临床肝胆病杂志, 2016, 32(2): 279-283. DOI: 10.3969/j.issn.1001-5256.2016.02.016
引用本文: 徐勇, 冯继红. 核苷和核苷酸类药物对慢性乙型肝炎患者肾小球滤过率和血肌酐水平的影响[J]. 临床肝胆病杂志, 2016, 32(2): 279-283. DOI: 10.3969/j.issn.1001-5256.2016.02.016
Xu Yong, Feng JiHong. Effects of nucleos(t) ide analogues on estimated glomerular filtration rate and serum creatinine level in patients with chronic hepatitis B[J]. J Clin Hepatol, 2016, 32(2): 279-283. DOI: 10.3969/j.issn.1001-5256.2016.02.016
Citation: Xu Yong, Feng JiHong. Effects of nucleos(t) ide analogues on estimated glomerular filtration rate and serum creatinine level in patients with chronic hepatitis B[J]. J Clin Hepatol, 2016, 32(2): 279-283. DOI: 10.3969/j.issn.1001-5256.2016.02.016

核苷和核苷酸类药物对慢性乙型肝炎患者肾小球滤过率和血肌酐水平的影响

DOI: 10.3969/j.issn.1001-5256.2016.02.016
详细信息
  • 中图分类号: R512.62

Effects of nucleos(t) ide analogues on estimated glomerular filtration rate and serum creatinine level in patients with chronic hepatitis B

  • 摘要: 目的研究核苷和核苷酸类药物(NAs)对慢性乙型肝炎(CHB)患者肾小球滤过率(e GFR)和血肌酐(Scr)的影响。方法收集2010年9月-2014年9月在大连医科大学附属第二医院感染科门诊及住院的CHB患者184例,根据应用NAs的不同将其分为3组,分别为阿德福韦酯(ADV)组(n=58)、替比夫定(LDT)组(n=62)和恩替卡韦(ETV)组(n=64),疗程均为104周。比较治疗前后各组e GFR、Scr水平的变化。计量资料组内治疗前后比较采用Wilcoxon秩和检验,多组间比较采用Kruskal-Wallis H秩和检验,计数资料组间比较采用χ2检验。结果 ETV组治疗52、104周后Scr、e GFR变化均不明显,与基线相比差异无统计学意义(P值均>0.05);与基线水平相比,ADV组治疗52、104周的Scr水平升高,e GFR水平降低,差异均有统计学意义(Z值分别为-3.020、-3.456、-4.623、-4.831,P值分别为0.018、0.008、0.004、<0.001);LDT组治疗52、104周的Scr水平较基线降低,e GFR较基线升高,差异均有...

     

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  • 收稿日期:  2015-06-05
  • 出版日期:  2016-02-20
  • 刊出日期:  2016-02-20
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