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Role of Wnt signaling pathway in progression of liver cirrhosis
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摘要:
肝硬化既往被认为不能逆转,但如果能抑制细胞外基质(ECM)的生成和促进ECM降解,理论上均可以延缓甚至逆转肝硬化的进展。Wnt信号通路参与人体多种生理病理过程,现已证实Wnt信号通路的异常激活能导致肝星状细胞的活化,从而激发ECM的形成并促进肝硬化的进展。综述了Wnt信号通路对肝硬化进展的影响,认为深入探讨Wnt信号通路对肝硬化的调控机制将给临床治疗肝硬化带来新的方向。
Abstract:In the past,liver cirrhosis was thought to be irreversible. However,theoretically,the process of liver cirrhosis could be slowed down by inhibiting extracellular matrix( ECM) production and by promoting its degradation. Wnt signaling pathway has been involved in many physiological and pathological processes and some studies have confirmed that abnormal activation of Wnt signaling pathway could cause activation of hepatic stellate cells,and then further induce ECM formation and prompt cirrhosis progression. We believe that new clinical therapeutic direction would emerge after in-depth exploration of the mechanism of Wnt signaling pathway involved in liver cirrhosis progression.
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Key words:
- liver cirrhosis /
- Wnt proteins /
- signal transduction /
- review
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