Objective To determine the Golgi protein-73( GP73) level and platelet( PLT) count in the peripheral blood of patients with hepatitis B virus( HBV)-related liver diseases and to investigate their values in diagnosing different stages of HBV-related liver diseases.Methods Peripheral blood samples were collected from 215 patients treated in Beijing Youan Hospital,including 36 patients with chronic hepatitis B( CHB),32 patients with liver cirrhosis( LC),and 147 patients with hepatocellular carcinoma( HCC). The level of GP73 was measured by ELISA and the PLT count was determined using the Automatic Hematology Analyzer. Comparison of continuous variables was performed using one-way ANOVA,and comparison of categorical variables using chi-square test. The correlation between different variables was assessed by liner regression analysis. Results GP73 level( ng / ml) and PLT count( × 109/ L) displayed similar changes between patients with CHB,LC,pro-early HCC,early HCC,progressive HCC,and advanced HCC. The GP73 level and PLT count were significantly lower in patients with pro-early HCC( 80. 5 ± 49. 8; 84. 4 ± 40. 0) than in those with CHB( 135. 5 ± 95. 8; 174. 4 ± 49. 9),progressive HCC( 133. 8 ± 71. 1; 122. 0 ± 70. 50),and advanced HCC( 192. 2 ± 98. 1; 176. 2 ± 86. 3)( all P < 0. 01). Conclusion GP73 level and PLT count change in patients with different stages of HBV-related diseases. The dynamic monitoring of GP73 level and PLT count is useful in the early diagnosis of HCC and the prognostic judgment of HCC patients.