Objective To analyze the correlation between malnutrition and prognosis in Uyghur pediatric patients with hepatitis A in Hetian of Xinjiang Uyghur Autonomous Region,China. Methods The clinical data of 342 children with hepatitis A admitted to the Infectious Disease Hospital of Hetian from January 2014 to May 2015 were retrospectively analyzed and the patients were divided into malnutrition group with 136 patients and normal nutrition group with 206 patients according to the Z- scores. The data of complete blood count,liver function test,biochemical indices,blood lipids,blood coagulation,and hospitalization days and costs were compared between the two groups. Comparison of categorical data between the two groups was made by chi- square test and comparison of continuous data between the two groups was made by t test. Results Compared with the normal nutrition group,the malnutrition group had significantly lower values of breastfeeding rate,hemoglobin,mean corpuscular volume,mean corpuscular hemoglobin,mean corpuscular hemoglobin concentration,serum iron,serum ferritin,glucose,serum albumin,and plasma thromboplastin antecedent but higher values of alanine transaminase,total bilirubin,total bile acid,cholesterol,and hospitalization days and costs( P < 0. 05). Conclusion Compared with the normal nutrition pediatric patients with hepatitis A,the malnutrition pediatric patients with hepatitis A have more severe iron deficiency anemia,hepatic damage,and abnormal metabolism of carbohydrates and fatty acids,so their recovery time is longer and the hospitalization costs are higher. To effectively protect Uygur children,hepatitis A vaccination in due course and the children's growth and development monitoring are recommended.