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Role of Hedgehog signaling pathway in progression of non-alcoholic fatty liver fibrosis
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摘要: 随着肥胖及其相关代谢综合征在全球范围内的广泛流行,非酒精性脂肪性肝病引起了国内外学者的广泛重视。非酒精性脂肪性肝纤维化是单纯性脂肪肝、脂肪性肝炎进展为肝硬化的关键环节和必经阶段。阐述了Hedgehog(Hh)信号通路对非酒精性脂肪性肝纤维化进程中肝细胞的作用,并对其进行了群体研究,表明Hh信号通路的异常激活推动了非酒精性脂肪性肝纤维化的进展。对Hh信号通路的深入研究可能为非酒精性脂肪性肝纤维化的治疗提供了一条新途径。Abstract: Obesity and related metabolic syndromes are prevalent on the global scale. Thus far,non- alcoholic fatty liver( NAFL) disease has caused wide attention from domestic and overseas scholars. NAFL cirrhosis is considered to be the central part and inevitable stage of liver cirrhosis developed from simple fatty liver and non- alcoholic steatohepatitis. The effect of Hedgehog signaling pathway on hepatocytes in the progression of NAFL fibrosis was elucidated and investigated by a population study. Results showed that abnormal activation of the Hedgehog signaling pathway promoted the progression of NAFL fibrosis. In- depth study on the Hedgehog signaling pathway may provide a new approach for the treatment of NAFL fibrosis.
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Key words:
- liver cirrhosis /
- fatty liver /
- hedgehog proteins /
- signal transduction /
- review
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