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New advances in pharmacological mechanism of silymarin and re-investigation of its clinical values
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摘要:
水飞蓟素作为传统的肝脏疾病辅助治疗药物已被证实具有显著的抗氧化、抗炎的药理作用。介绍了水飞蓟素调整肝脏功能及拮抗纤维化、保护胰腺细胞、抑制肿瘤细胞生长及抗HCV的作用机制。认为水飞蓟素作为一种天然药物,独具大剂量使用毒副作用低等优点,在抗肿瘤、抗氧化、抗炎、抗病毒等方面具有良好的应用前景。
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关键词:
- 水飞蓟素 /
- 药理作用分子作用机制 /
- 肝脏 /
- 胰腺 /
- 综述
Abstract:Silymarin is a traditional hepatoprotective herb for the adjuvant therapy of liver diseases,which shows marked pharmacological activities such as antioxidant and anti- inflammatory properties. This paper introduces the action mechanism of silymarin in regulating liver function,ameliorating hepatic fibrosis,protecting pancreatic cells,suppressing the growth of tumor cells,and inhibiting the replication of hepatitis C virus. Silymarin is considered to be a natural medicine with little toxic or side effect at a high dose. It holds promise for anti-tumor,antioxidant,anti- inflammatory,and antiviral application.
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Key words:
- silymarin /
- molecular mechnisms of pharmacological action /
- liver /
- pancreas /
- review
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