原发性胆汁性肝硬化的流行病学与自然史变迁

王立峰; 李元元; 金磊; 王福生

doi:10.3969/j.issn.1001-5256.2015.02.005

原发性胆汁性肝硬化的流行病学与自然史变迁

DOI: 10.3969/j.issn.1001-5256.2015.02.005

解放军第三○二医院肝病生物治疗研究中心

基金项目:

国家自然科学基金(81470837,81302593,81101589)；解放军302医院院内课题(YNKT2013023)；天晴肝病研究基金(CFHPC20132094)；

详细信息

中图分类号: R575.22
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出版历程
- 出版日期: 2015-02-20

Epidemiology and natural history of primary biliary cirrhosis

Liver Disease Research Center for Biological Therapy, 302 Hospital of PLA

Research funding:

摘要

摘要:
原发性胆汁性肝硬化(PBC)是一种自身免疫介导的胆汁淤积性肝病。全面介绍了不同国家和不同地区PBC的流行病学情况,并针对熊去氧胆酸药物广泛应用前后,PBC自然史的变迁进行了分析,同时对我国近些年在PBC研究领域所取得的成绩进行了总结。尽管我国在PBC的诊疗方面取得了很大的进步,但仍然与西方国家存在差距。认为进一步提高基层医生和患者自身对该疾病的认识、成立中国多中心联合的PBC研究组、深入探索PBC的发病机制,将为我国PBC患者的有效治疗奠定重要的基础。
- 肝硬化,胆汁性 /
- 流行病学 /
- 熊去氧胆酸
Abstract:
Primary biliary cirrhosis( PBC) is an autoimmune cholestatic liver disease. In this review,the epidemiology of PBC,which varies in different countries and regions,is comprehensively introduced. Furthermore,the natural history of PBC before and after the wide application of ursodeoxycholic acid is analyzed. Also,recent advances in the study field of PBC in China are summarized. However,we still lag far behind Western countries concerning the diagnosis and treatment of PBC. Therefore,we believe further improving the knowledge of PBC among primary care physicians and PBC patients,setting up the multi- center PBC study group in China,and probing into the pathogenesis of this disease would pave the way for effective treatment of PBC patients in China.
- liver cirrhosis,biliary /
- epidemiology /
- ursodeoxycholic acid