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Research advances in primary biliary cirrhosis
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摘要:
原发性胆汁性肝硬化(PBC)是近百年间发现的一种与免疫相关的慢性进行性胆汁淤积性肝病,其病因及发病机制至今不详。对PBC的命名由来、近年来针对PBC的相关研究进展以及未来PBC患者治疗的展望进行概述,认为熊去氧胆酸可有效改善PBC胆汁淤积状态。但无论是PBC的命名、发病相关危险因素,还是应答标准及治疗等都仍需进一步探讨与深入研究。
Abstract:Primary biliary cirrhosis( PBC) is a chronic progressive cholestatic liver disease associated with immunity,with unknown etiology and pathogenesis. This article reviews the origin of its name,recent advances in research on PBC,and the prospect of treatment. Ursodeoxycholic acid is considered to be effective in improving cholestasis among PBC patients,but its naming and risk factors,as well as the response criteria and treatment,still need further research.
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Key words:
- liver cirrhosis,biliary /
- treatment outcome /
- ursodeoxycholic acid
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