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Late-onset abnormal elevation of transaminase after hepatectomy indicates high risk of death
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摘要:
目的总结肝切除术后转氨酶延迟异常升高的临床意义。方法对本中心2009年3月至2012年3月收治的15例肝脏部分切除术后转氨酶异常升高(AST或ALT>3000 U/L)患者的临床资料进行回顾,统计患者的疾病类型、手术相关信息、术后临床指标和随访数据,分析转氨酶升高的时间、程度与临床预后之间的关系。组间比较采用t检验和χ2检验。结果术后转氨酶异常升高存在2种不同的群体,在围手术期生存病例和死亡病例在术后转氨酶异常升高时间(t=3.732,P=0.003)、升高持续时间(t=3.542,P=0.004)和转氨酶峰值(t=2.993,P=0.010)等方面差异有统计学意义。结论肝切除术后转氨酶异常升高是少见的临床现象,在术后3~5 d出现延迟转氨酶升高的患者预后不良,应当引起足够的临床重视。
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关键词:
- 肝切除术 /
- 丙氨酸转氨酶 /
- 天冬氨酸氨基转移酶类
Abstract:Objective To investigate the clinical significance of late- onset abnormal elevation of transaminase after hepatectomy. Methods A retrospective analysis was performed on the clinical data of 15 patients with abnormal elevation of transaminase after partial hepatectomy, who were admitted to our center from March 2009 to March 2012. The clinical implication of different types of late- onset elevation of transaminase was analyzed. Comparison between groups was made by t test or chi- square test. Results There were two different populations with abnormal elevation of transaminase after operation. There were differences in time of postoperative transaminase elevation, duration of transaminase elevation, and peak level of transaminase between survival cases and death cases. Conclusion Abnormal elevation of transaminase after hepatectomy is not commonly seen in clinical practice. The patients with late- onset elevation of transaminase at 3- 5 d after operation have poor prognosis, which should be given enough attention.
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Key words:
- hepatectomy /
- alanine transaminase /
- aspartate aminotransferases
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