重症急性胰腺炎患者早期血液流变学及血管活性指标血栓素A2、前列环素I2水平变化

梁超; 沙盈盈; 朱晓明; 王雄达; 朱玉华; 赵震宇

doi:10.3969/j.issn.1001-5256.2014.06.018

重症急性胰腺炎患者早期血液流变学及血管活性指标血栓素A2、前列环素I2水平变化

DOI: 10.3969/j.issn.1001-5256.2014.06.018

上海中医药大学附属岳阳中西医结合医院普外科

基金项目:

上海市教育委员会科研创新项目(2012JW50)；

详细信息

中图分类号: R576
计量
- 文章访问数: 2425
- HTML全文浏览量: 22
- PDF下载量: 569
- 被引次数: 0
出版历程
- 收稿日期: 2014-01-15
- 出版日期: 2014-06-20

Early changes in hemorheological parameters and TXA2 and PGI2 levels among patients with severe acute pancreatitis

Department of General Surgery, Yueyang Hospital of Integrative Chinese & Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

Research funding:

摘要

摘要: 目的观察重症急性胰腺炎(SAP)患者早期血液流变学指标及血栓素A2(TXA2)、前列环素I2(PGI2)的变化。方法2012年1月至2013年9月住院的32例SAP患者为SAP组,30例体检健康人为NC组。于患者入院后治疗前即静脉采血,平行检测血液流变学指标及血浆TXA2、PGI2水平,并计算TXA2、PGI2比值。结果比较进行t检验。结果 SAP组血液流变学中除红细胞变形指数低于NC组(t=2.185,P<0.05)外,全血高、中、低切黏度、血浆黏度高于NC组(t=2.820、2.755、2.700、3.622,P<0.05),全血高切还原黏度、全血低切还原黏度高于NC组(t=3.391、2.018,P<0.05),红细胞压积、红细胞刚性指数、红细胞聚集指数高于NC组(t=2.980、2.209、2.004,P<0.05)、全血高切相对指数、全血低切相对指数高于NC组(t=2.630、2.440,P<0.05);SAP组TXA2、PGI2、TXA2、PGI2比值高于NC组(t=3.256、2.589、2.640,P<0.05)。结论 SAP患者早期...
- 胰腺炎,急性坏死性 /
- 血液流变学 /
- 受体,血栓烷A2,前列腺素H2 /
- 依前列醇
Abstract: Objective To investigate the early changes in hemorheological parameters and thromboxane A2 ( TXA2) and prostacyclin ( PGI2) levels among patients with severe acute pancreatitis ( SAP) . Methods Thirty-two SAP patients hospitalized from January 2012 to September 2013 were selected as SAP group; 30 healthy controls were selected as normal control ( NC) group. Venous blood was collected after admission and before treatment. The hemorheological parameters and plasma levels of TXA2and PGI2were determined, and TXA2/PGI2ratio was calculated. Comparison between groups was made by t test. Results Compared with the NC group, the SAP group had a significantly lower erythrocyte deformation index ( t = 2. 185, P < 0. 05) , significantly higher whole blood viscosities at high-, middle-, and low- shear rates and plasma viscosity ( t = 2. 820, 2. 755, 2. 700, and 3. 622, P < 0. 05) , significantly higher whole blood reduced viscosities at high- and low- shear rates ( t = 3. 391 and 2. 018, P < 0. 05) , a significantly higher hematocrit ( t = 2. 980, P < 0. 05) , a significantly higher erythrocyte rigidity index ( t = 2. 209, P < 0. 05) , a significantly higher erythrocyte aggregation index ( t = 2. 004, P < 0. 05) , a significantly higher whole blood relative index at high shear rate ( t = 2. 630, P < 0. 05) , a significantly higher whole blood relative index at low shear rate ( t = 2. 440, P < 0. 05) , a significantly higher TXA2level ( t = 3. 256, P < 0. 05) , a significantly higher PGI2level ( t =2. 589, P < 0. 05) , and a significantly higher TXA2/PGI2ratio ( t = 2. 640, P < 0. 05) . Conclusion Hemorheological disorders and increased activity of vascular endothelial cells appear in the early stage in SAP.
- pancreatitis, acute necrotizing /
- hemorheology /
- receptors, thromboxane A2, prostaglandin H2 /
- epoprostend

HTML全文

参考文献(8)

[1]DLUGOSZ JW, NOWAK K, LASZEWICZ W, et al.The effect of endothelin-1 receptor antagonists in acute experimental pancreatitis in the rats[J].Exp Toxicol Pathol, 2010, 55 (2-3) :137-145.

[2]TOORLI J, BROOKE-SMITH M, BASSI C, et al.Guidelines for the management of acute pancreatitis[J].Gastroen Cerol Hepatol, 2002, 7 (17) :15-39.

[3]KOTAN R, NEMETH N, KISS F, et al.Micro-rheological changes during experimental acute pancreatitis in the rat[J].Clin Hemorheol Microcirc, 2012, 51 (4) :255-264.

[4]BROWN A, JAMES-STEVENSON T, DYSON T, et al.The panc3 score:a rapid and accurate test for predicting severity on presebtation in acute pancreatitis[J].J Clin Gastroenternal, 2007, 41 (9) :855-858.

[5]KINNALA PJ, KUTTILA KT, GRONROOS JM, et al.Pancreatic tissue purfusion in experimental acute pancreatitis[J].Eur J Surg, 2008, 16 (9) :689-694.

[6]ZHOU YK, WU Y.The relationship between hemorheology and multiple organ failure of acute pancreatitis in rats[J].World Chin J Dig, 2000, 8 (9) :1055-1057. (in Chinese) 周亚魁, 吴云.急性胰腺炎鼠血液流变学与多器官损害的相关性[J].世界华人消华杂志, 2000, 8 (9) :1055-1057.

[7]ZHAO XY, XIA SH.Platelet activating factor and development and treatment of acute pancretitis[J].World Chin J Dig, 2001, 9 (8) :958-960. (in Chinese) 赵晓晏, 夏时海.血小板活化因子与急性胰腺炎的发生和治疗[J].世界华人消化杂志, 2001, 9 (8) :958-960.

[8]XIA SH, ZHAO XY, GUO P, et al.Hemocirculatory disorder in dogs with severe acute pancreatitis and intervention of platelet activating factor antagonis[J].World Chin J Dig, 2005, 9 (5) :550-555. (in Chinese) 夏时海, 赵晓晏, 郭萍, 等.犬重症急性胰腺炎血循环障碍及血小板活化因子拮抗剂的干预[J].世界华人消化杂志, 2005, 9 (5) :550-555.

施引文献

资源附件(0)

访问统计