原发性胆汁性肝硬化患者血清抗gp210抗体检测的意义

李银萍; 牛俊奇

doi:10.3969/j.issn.1001-5256.2014.05.023

原发性胆汁性肝硬化患者血清抗gp210抗体检测的意义

DOI: 10.3969/j.issn.1001-5256.2014.05.023

吉林大学第一医院肝胆胰内科

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中图分类号: R575.22
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出版历程
- 出版日期: 2014-05-20

Significance of serum anti-gp210 antibody detection in diagnosis of primary biliary cirrhosis

摘要

摘要:
原发性胆汁性肝硬化(PBC)是一种以肝内小胆管进行性破坏为特征,并可在一定时期内进展为肝硬化的慢性疾病。抗线粒体抗体,尤其是抗M2抗体对于诊断PBC具有很高价值,但其与PBC病情程度及预后无关,且部分患者该抗体阴性。国内外已有文献报道抗核抗体特别是抗gp210抗体,与PBC的关系密切。归纳显示,抗gp210抗体诊断PBC特异性及敏感性均较高,且对于抗M2抗体阴性的PBC有更高检测价值,另外,其对于评估PBC预后及疾病发展模式有良好的预测价值。认为抗gp210抗体具有较高的检测意义及临床价值,值得广泛推广。
- 肝硬化,胆汁性 /
- 抗gp210抗体 /
- 综述
Abstract:
Primary biliary cirrhosis ( PBC) is a chronic disease characterized by progressive destruction of intrahepatic small bile ducts, which may progress to liver cirrhosis. Anti- mitochondrial antibodies, especially anti- M2 antibody, have a high diagnostic value for PBC, but they are unrelated to the severity and prognosis of the disease and are negative in some patients. There have been reports from around the world that anti- nuclear antibodies, especially anti- gp210 antibody, are closely associated with PBC. It showed that anti- gp210 antibody has high specificity and sensitivity for the diagnosis of PBC, especially for the patients with negative anti- M2 antibody tests; in addition, it has a high predictive value for the prognosis and development model of the disease. Anti- gp210 antibody has a high diagnostic value for PBC, with great clinical significance, so its detection holds promise for clinical application.
- liver cirrhosis, biliary /
- anti gp210 antibody /
- review

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参考文献(25)

[1]WANG YH, YANG W, GERSHWIN ME, et al.Cellular mechanism of immunopathogenesis of primary biliary cirrhosis[J].J Clin Hepatol, 2011, 27 (6) :584-587. (in Chinese) 王寅虎, 杨微, GERSHWIN ME, 等.原发性胆汁性肝硬化的细胞免疫学发病机制[J].临床肝胆病杂志, 2011, 27 (6) :584-587.

[2]HIRSCHFIELD GM.Diagnosis of primary biliary cirrhosis[J].Best Pract Res Clin Gastroenterol, 2011, 25 (6) :701-712.

[3]HU CJ, ZHANG FC, LI YZ, et al.Primary biliary cirrhosis:What do autoantibodies tell us?[J].World J Gastroenterol, 2010, 16 (29) :3616-3629.

[4] GRANITO A, MURATORI P, QUARNETI C, et al.Antinuclear antibodies as ancillary markers in primary biliary cirrhosis[J].Expert Rev Mol Diagn, 2012, 12 (1) :65-74.

[5]RUFFATTI A, ARSLAN P, FLOREANI A, et al.Nuclear membrane-staining antinuclear antibody in patients with primary biliary cirrhosis[J].J Clin Immunol, 1985, 5 (5) :357-361.

[6]COURVALIN JC, LASSOUED K, BARTNIK E, et al.The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore[J].J Clin Invest, 1990, 86 (1) :279-285.

[7]NICKOWITZ RE, WOZNIAK RW, SCHAFFNER F, et al.Autoantibodies against integral membrane proteins of the nuclear envelope in patients with primary biliary cirrhosis[J].Gastroenterology, 1994, 106 (1) :193-199.

[8]BANDIN O, COURVALIN JC, POUPON R, et al.Specificity and sensitivity of gp210 autoantibodies detected using an enzymelinked immunosorbent assay and a synthetic polypeptide in the diagnosis of primary biliary cirrhosis[J].Hepatology, 1996, 23 (5) :1020-1024.

[9]BAUER A, HABIOR A.Measurement of gp210 autoantibodies in sera of patients with primary biliary cirrhosis[J].J Clin Lab Anal, 2007, 21 (4) :227-231.

[10]MILKIEWICZ P, BUWANESWARAN H, COLTESCU C, et al.Value of autoantibody analysis in the differential diagnosis of chronic cholestatic liver disease[J].Clin Gastroenterol Hepatol, 2009, 7 (12) :1355-1360.

[11]XIAO H, CHEN JW, XIE X, et al.Diagnostic significance of autoantibodies in patients with primary biliary cirrhosis[J].J Peking Univ:Health Sci, 2012, 44 (2) :209-214. (in Chinese) 肖华, 陈进伟, 谢希, 等.自身抗体检测在原发性胆汁性肝硬化诊断中的价值[J].北京大学学报:医学版, 2012, 44 (2) :209-214.

[12]GSTSELIS NK, ZACHOU K, NORMAN GL, et al.Clinical significance of the fluctuation of primary biliary cirrhosis-related autoantibodies during the course of the disease[J].Autoimmunity, 2013.

[13]WU J, ZENG KQ, WANG MJ, et al.Diagnostic value of gp210 and sp100 antibodies in patients with primary biliary cirrhosis[J].China J Modern Med, 2012, 22 (34) :55-57. (in Chinese) 武剑, 曾克勤, 王鸣军, 等.抗gp210、Sp100抗体对原发性胆汁性肝硬化的诊断意义[J].中国现代医学杂志, 2012, 22 (34) :55-57.

[14]DU HH, LI QM, ZHOU XZ, et al.Diagnostic value of a variety of autoantibodies detection in patients with primary biliary cirrhosis[J].Chin J Liver Dis:Electron Vers, 2013, 5 (1) :19-23. (in Chinese) 杜慧慧, 李青梅, 周希禛, 等.多种自身抗体联合检测在原发性胆汁性肝硬化中的诊断价值[J].中国肝脏病杂志:电子版, 2013, 5 (1) :19-23.

[15]NAKAMURA M, TAKII Y, KOMORI A, et al.Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis[J].J Hepatology, 2005, 42 (3) :386-392.

[16]MURATORI P, MURATORI L, FERRRARI R, et al.Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis[J].Am J Gastroenterol, 2003, 98 (2) :431-437.

[17]GAO L, TIAN X, LIU B, et al.The value of antinuclear antibodies in primary biliary cirrhosis[J].Clin Exp Med, 2008, 8 (1) :9-15.

[18]HU CJ, DENG CW, SONG G, et al.Prevalence of autoimmune liver disease related autoantibodies in Chinese patients with primary biliary cirrhosis[J].Dig Dis Sci, 2011, 56 (11) :3357-3363.

[19]LIU HH, FU JL, XU J, et al.Clinical manifestation and autoantibody profile in 123 patients with primary biliary cirrhosis[J].J Peking Univ:Health Sci, 2013, 45 (2) :233-237. (in Chinese) 刘红虹, 福军亮, 徐军, 等.123例原发性胆汁性肝硬化临床表现与自身抗体谱[J].北京大学学报:医学版, 2013, 45 (2) :233-237.

[20]WORMAN HJ, COURVALIN JC.Antinuclear antibodies specific for primary biliary cirrhosis[J].Autoimmunity Reviews, 2003, 2 (4) :211-217.

[21]ITOH S, ICHIDA T, YOSHIDA T, et al.Autoantibodies against a210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis[J].J Gastroenterol Hepatol, 1998, 13 (3) :257-265.

[22]ISHIBASHI H, KOMORI A, SHIMODA S, et al.Risk factors of prediction of long-term outcome in primary biliary cirrhosis[J].Intern Med, 2011, 50 (1) :1-10.

[23]NAKAMURA M, KONDO H, MORI T, et al.Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis[J].Hepatology, 2007, 45 (1) :118-127.

[24]LIU HH, FU JL, FU BY, et al.The pathogenesis and risk factors related to prognosis of primary biliary cirrhosis[J].J Clin Hepatol, 2012, 28 (2) , 153-155. (in Chinese) 刘红虹, 福军亮, 付宝云, 等.原发性胆汁性肝硬化的发病机制及影响预后的危险因素研究进展[J].临床肝胆病杂志, 2012, 28 (2) :153-155.

[25]NAKAMURA M, TAKII Y, ITO M, et al.Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis[J].J Autoimmun, 2006, 26 (2) :138-145.

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