细胞自噬在肝脏疾病中的作用

黄兰蔚; 徐列明

doi:10.3969/j.issn.1001-5256.2014.02.022

细胞自噬在肝脏疾病中的作用

DOI: 10.3969/j.issn.1001-5256.2014.02.022

1. 上海曙光医院宝山分院
2. 上海中医药大学肝病研究所,上海中医药大学附属曙光医院

详细信息

中图分类号: R575
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出版历程
- 收稿日期: 2013-05-02
- 出版日期: 2014-02-20

Relationship between liver diseases and autophagy

Shanghai Shuguang Hospital Baoshan Branch

摘要

摘要: 近年来,越来越多的证据表明细胞自噬在慢性肝炎病毒感染、酒精性肝病、脂肪肝等各种类型的肝脏疾病的发生发展中起到重要作用,成为关注和研究的新焦点。自噬是指细胞利用溶酶体大范围降解长寿命蛋白质、大分子物质、核糖体及受损细胞器的过程。简述了各种肝脏疾病与细胞自噬的关系,认为探索细胞自噬在肝病机制中所扮演的角色,将可能成为治疗肝脏疾病的一个新靶点。
- 自噬 /
- 肝疾病 /
- 综述
Abstract: Recent studies have found more and more evidence that autophagy plays an important role in the development and progression of various liver diseases such as chronic hepatitis virus infection, alcoholic liver disease, and fatty liver, and it has become a new focus of attention and research. Autophagy is a process of large- scale lysosomal degradation of long- lived proteins, macromolecules, ribosomes, and damaged organelles. The relationship between various liver diseases and autophagy is reviewed. It is thought that the role of autophagy in the pathogenesis of liver diseases will probably become a new therapeutic target for liver diseases.
- autophagy /
- liver diseases /
- review

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参考文献(24)

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