白细胞介素与HBV感染的关系

费筠; 陈月; 吴文苑

doi:10.3969/j.issn.1001-5256.2014.02.019

白细胞介素与HBV感染的关系

DOI: 10.3969/j.issn.1001-5256.2014.02.019

暨南大学第二临床医学院,深圳市人民医院检验科

基金项目:

广东省自然科学基金(07300964)；深圳市医疗卫生类科研项目(201302017)；

详细信息

中图分类号: R512.62
计量
- 文章访问数: 2821
- HTML全文浏览量: 19
- PDF下载量: 628
- 被引次数: 0
出版历程
- 出版日期: 2014-02-20

Research advances in relationship between interleukins and hepatitis B virus infection

Research funding:

摘要

摘要:
HBV进入宿主体内后,多种免疫细胞及其分泌的细胞因子参与了机体的免疫应答。白细胞介素是一类对免疫应答各个环节都有重要调节作用的细胞因子,介绍了几种在乙型肝炎发生、发展及转归中作用较大的白细胞介素及其与HBV感染的相关性,分析表明对白细胞介素免疫调节机制的深入研究可为各种类型乙型肝炎的诊断和治疗提供新的依据和方法。
- 白细胞介素类 /
- 肝炎病毒,乙型 /
- 肝炎,乙型,慢性 /
- 免疫,主动 /
- 综述
Abstract:
A variety of immunocytes and their cytokines participate actively in the immune responses to hepatitis B virus ( HBV) in the host body. As a class of important cytokines, interleukins play regulatory effects in all aspects of immune responses. Several interleukins which play a significant role in the development, progression, and outcome of hepatitis B and their relationship with HBV infection are reviewed. Analysis showed that in- depth research on the immunoregulatory mechanisms of interleukins can offer new basis and method for the diagnosis and treatment of various types of hepatitis B.
- interleukins /
- hepatitis B virus /
- hepatitis B, chronic /
- inmunity, active /
- review

HTML全文

参考文献(25)

[1]LIU M, MIAO T, ZHU H, et al.IL-2-engineered nano-APC effectively activates viral antigen-mediated T cell responses from chronic hepatitis B virus-infected patients[J].J Immunol, 2012, 188 (3) :1534-1543.

[2]YAO Y, LI J, LU Z, et al.Proteomic analysis of the interleukin-4 (IL-4) response in hepatitis B virus-positive human hepatocelluar carcinoma cell line HepG2.2.1.5[J].Electrophoresis, 2011, 32 (15) :2004-2012.

[3]WANG XH, CAO Q, HU CM.JAK/STAT pathway mediates IL-4-induced typeⅠcollagen expression in human hepatic stellate cell line LX-2[J].Basic Clin Med, 2012, 32 (4) :423-427. (in Chinese) 王晓红, 曹琦, 胡成穆.JAK/STAT通路调节IL-4诱导的肝星状细胞系LX-2Ⅰ型胶原基因的表达[J].基础医学与临床, 2012, 32 (4) :423-427.

[4]KAO JT, LAI HC, TSAI SM, et al.Rather than interleukin-27, interleukin-6 expresses positive correlation with liver severity in nave hepatitis B infection patients[J].Liver Int, 2012, 32 (6) :928-936.

[5]ZUO WZ, XU CM, SHEN LC.Changes in serum level of interleukin-32 and interleukin-6 in patients with chronic hepatitis B virus infection and its clinical significance[J].J Clin Hepatol, 2011, 27 (4) :408-410. (in Chinese) 左维泽, 许春梅, 沈兰超.乙型肝炎患者血清白细胞介素-32、白细胞介素-6水平变化及临床意义[J].临床肝胆病杂志, 2011, 27 (4) :408-410.

[6]WANG MF, YANG WT, YANG GL, et al.The immunoregulatory effects and clinical application[J].Chin J Immunol, 2012, 28 (11) :1046-1050. (in Chinese) 王美芳, 杨文涛, 杨桂连, 等.白细胞介素10的免疫调节作用及临床应用[J].中国免疫学杂志, 2012, 28 (11) :1046-1050.

[7]MENG J, CHENG SQ.Effects and clinical significance of Entecavir for interleukin-10 and transformer growth factor-βof patients with chronic hepatitis B[J].China Med Herald, 2013, 10 (20) :74-76. (in Chinese) 孟杰, 程书权.恩替卡韦对慢性乙型肝炎患者血清白细胞介素10和转化生长因子β1的影响及临床意义[J].中国医药导报, 2013, 10 (20) :74-76.

[8]DAS A, ELLIS G, PALLANT C, et al.IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection[J].J Immunol, 2012, 189 (8) :3925-3935.

[9]SCHURICH A, PALLETT LJ, LUBOWIECKI M, et al.The third signal cytokine IL-12 rescues the anti-viral function of exhausted HBV-specific CD8 T cells[J].PLoS Pathog, 2013, 9 (3) :e1003208.

[10]HE D, YAN G, WANG Y.Serum levels of interleukin-12 in various clinical states with hepatitis B virus infection[J].Cell Immunol, 2012, 272 (2) :162-165.

[11]WU JF, WU TC, CHEN CH, et al.Serum levels of interleukin-10 and interleukin-12 predict early, spontaneous hepatitis B virus e antigen seroconversion[J].Gastroenterology, 2010, 138 (1) :165-172.

[12]WANG B, ZHAO XP, FAN YC, et al.IL-17A but not IL-22suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line[J].Antiviral Res, 2013, 97 (3) :285-292.

[13]ZHANG JY, ZHANG Z, LIN F, et al.Interleukin-17-producing CD4 (+) T cells increase with severity of liver damage in patients with chronic hepatitis B[J].Hepatology, 2010, 51 (1) :81-91.

[14]DU WJ, ZHEN JH, ZENG ZQ, et al.Expression of Interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection:IL-17 in HBV infection[J].Diagn Pathol, 2013, 8:40.

[15]WANG Q, ZHOU J, ZHANG B, et al.Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23/IL-17 Axis[J].PLoS Pathog, 2013, 9 (6) :e1003410.

[16]TU Z, HAMALAINEN-LAANAYA HK, CRISPE IN, et al.Synergy between TLR3 and IL-18 promotes IFN-γdependent TRAIL expression in human liver NK cells[J].Cell Immunol, 2011, 271 (2) :286-291.

[17]HE R, LI GJ, WU JZ, et al.IL-18 expression and clinical significance of HBV infection-related chronic liver disease[J].Cur Immunol, 2011, 31 (2) :143-145. (in Chinese) 贺荣, 李国坚, 吴继周, 等.HBV感染相关性慢性肝病IL-18的表达及临床意义研究[J].现代免疫学, 2011, 31 (2) :143-145.

[18]YAMAMOTO N, MURATA K, YONEDA K, et al.Protective role of interleukin-18 against Fas-mediated liver injury[J].Int J Mol Med, 2008, 22 (1) :43-48.

[19]ZHANG Y, COBLEIGH MA, LIAN JQ, et al.A proinflammatory role for interleukin-22 in the immune response to hepatitis B virus[J].Gastroenterology, 2011, 141 (5) :1897-1906.

[20]FENG D, KONG X, WENG H, et al.Interleukin-22 promotes proliferation of liver stem/progenitor cells in mice and patients with chronic hepatitis B virus infection[J].Gastroenterology, 2012, 143 (1) :188-198.

[21]COBLEIGH MA, ROBEK MD.Protective and pathological properties of IL-22 in liver disease:implications for viral hepatitis[J].Am J Pathol, 2013, 182 (1) :21-28.

[22]XIANG X, GUI H, KING NJ, et al.IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus-infected liver[J].Immunol Cell Biol, 2012, 90 (6) :611-619.

[23]GAO K, ZHANG LF.Interleukin and tumor research progress[J].Chin J Immunol, 2012, 28 (5) :467-473. (in Chinese) 高昆, 张连峰.白细胞介素与肿瘤研究进展[J].中国免疫学杂志, 2012, 28 (5) :467-473.

[24]WANG HL, ZHANG HY, ZHAI ZL, et al.The correlation between hepatitis B virus infection and IL-27[J].Biomed Mater Eng, 2012, 22 (1-3) :187-193.

[25]YOSHIMOTO T, YOSHIMOTO T, YASUDA K, et al.IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells:a novel therapeutic way for Th2-mediated allergic inflammation[J].J Immunol, 2007, 179 (7) :4415-4423.

施引文献

资源附件(0)

访问统计