HCV基因异质性及其宿主基因多态性

聂永红; 许春梅

doi:10.3969/j.issn.1001-5256.2013.10.019

HCV基因异质性及其宿主基因多态性

DOI: 10.3969/j.issn.1001-5256.2013.10.019

金昌市疾病预防控制中心

详细信息

中图分类号: R512.63
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出版历程
- 收稿日期: 2012-12-07
- 出版日期: 2013-10-20

HCV genetic heterogeneity and its host genetics

Jinchang Center for Disease Control and Prevention

摘要

摘要: 丙型肝炎的进展、严重程度、治疗反应性差异不仅与病毒的遗传多样性有关,而且与宿主IL-28B、IP-10、ITPA基因多态性有关。分别介绍了HCV基因多态性和宿主基因单核苷酸多态性的分子流行病学、临床和治疗学方面的研究进展,提出迫切需要可靠的有关病毒及宿主的相关分子流行病学数据,以协助决策HCV筛检等公共卫生问题,降低丙型肝炎全球发病率和病死率。
- 肝炎,丙型 /
- 肝炎病毒,丙型 /
- 遗传异质性 /
- 遗传学
Abstract: Hepatitis C represents a major worldwide public health problem. Studies have shown that both genetic diversity of hepatitis C virus ( HCV) and genetic polymorphisms of IL- 28B, ITPA, and IP- 10 in the host are implicated in the progression of hepatitis C, treatment response, and adverse effects. The research advances in the molecular epidemiology and clinical and therapeutic interventions of HCV genetic heterogeneity and single nucleotide polymorphisms in its host are reviewed. It is suggested that there is a pressing need for reliable data on the molecular epidemiology of HCV and its host, which will assist in the decision making of public health issues and reduce the morbidity and mortality of hepatitis C worldwide.
- hepatitis C /
- hepatitis C virus /
- genetic heterogeneity /
- genetics

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参考文献(39)

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