信号传导和转录激活因子3调控肝癌侵袭转移的研究进展

苟泽鹏; 王德盛; 周亮; 祝普利; 张勇; 孙伟

信号传导和转录激活因子3调控肝癌侵袭转移的研究进展

第四军医大学西京医院肝胆胰脾外科

基金项目:

国家自然科学基金(30872480)；

详细信息

中图分类号: R735.7
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出版历程
- 出版日期: 2012-04-20

The research progress of STAT3 on the regulation of hepatocellular carcinoma invasion and metastasis

Research funding:

摘要

摘要: 信号传导和转录激活因子(STAT3)是一种信号转导蛋白和转录激活物,可被多种细胞因子激活。被活化的STAT3能转录并激活下游靶基因,引起一系列细胞相关因子的异常表达,与多种恶性肿瘤的发生、发展和侵袭转移关系密切。STAT3在肝癌的发生和发展中同样起着非常重要的作用。本文就其结构、功能及其与肝癌侵袭、转移的研究进展进行综述。
- STAT3转录因子 /
- 肝肿瘤 /
- 肿瘤侵润 /
- 肿瘤转移
Abstract: STAT3 is a signal transduction protein and transcriptional activator, which can be activated by a variety of cytokines.The activated STAT3 could cause abnormal expression of a series of cell-associated factors by transcripting and activating the downstream target genes.It is closely related with the occurrence, development, invasion and metastasis of multiple malignancies.STAT3 plays a very important role in the occurrence and development of hepatocellular carcinoma.This paper focuses on the STAT3′s structure, function and relation between invasion and metastasis of hepatocellular carcinoma.
- STAT3 transcription factor /
- liver neoplasms /
- neoplasm invasion /
- neoplasm metastasis

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参考文献(34)

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