Ras/ERK信号转导通路在肝纤维化发生发展中的作用

李俊峰; 邓永东; 张立婷; 陈红

Ras/ERK信号转导通路在肝纤维化发生发展中的作用

兰州大学第一医院感染科

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中图分类号: R575.2
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出版历程
- 出版日期: 2011-03-20

The role of Ras/ERK signal transduction pathway in the occurrence and development of hepatic fibrosis

摘要

摘要: 在肝纤维化的发病机制中,肝星状细胞(HSC)发挥关键的作用。各种细胞因子的分泌,引起胞外信息变化。细胞因子与HSC上的相应受体结合,激活多条信号转导通路,将胞外信息转导入核,调控基因的转录和表达,从而引起胶原分泌增多、细胞基质降解和沉积失衡。在参与肝纤维化发生发展的信号转导通路中,Ras/ERK信号转导通路介导的信号转导促使了肝纤维化的发生发展。
- 肝硬化 /
- 信号传导 /
- Ras蛋白质类 /
- 蛋白质丝氨酸苏氨酸激酶
Abstract: Hepatic stellate cells play a key role in the pathogenesis of hepatic fibrosis..The secretion of various cytokines lead to changes in extracellular information.The secreted cytokines bind to the corresponding receptors on hepatic stellate cells and then activate multiple signal transduction pathways, and extrinsic information of cells is transferred into the nucleus.It regulates the transcription and expression of gene, causing an increase in collagen secretion and an imbalance of cell matrix degradation and deposition.In the pathways involved in the occurrence and development of hepatic fibrosis, the signal transduction mediated by Ras/ERK signal transduction pathway prompts the occurrence and development of hepatic fibrosis.
- live cirrhosis /
- signal transduction /
- Ras proteins /
- protein serine threonine kinases

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参考文献(28)

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