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艾滋病病毒/丙型肝炎病毒双重感染者的艾滋病病毒特异性CTL应答

康文臻 黄德东 李媛 庄严 翟嵩 赵柯 谢玉梅 孙永涛

康文臻, 黄德东, 李媛, 庄严, 翟嵩, 赵柯, 谢玉梅, 孙永涛. 艾滋病病毒/丙型肝炎病毒双重感染者的艾滋病病毒特异性CTL应答[J]. 临床肝胆病杂志, 2011, 27(1): 68-71+80.
引用本文: 康文臻, 黄德东, 李媛, 庄严, 翟嵩, 赵柯, 谢玉梅, 孙永涛. 艾滋病病毒/丙型肝炎病毒双重感染者的艾滋病病毒特异性CTL应答[J]. 临床肝胆病杂志, 2011, 27(1): 68-71+80.
Kang WenZhen, Huang DeDong, Li Yuan, Zhuang Yan, Zhai Song, Zhao Ke, Xie YuMei, Sun YongTao. HIV-specific cytotoxic T-lymphocyte responses in patients co-infected with HIV and HCV[J]. J Clin Hepatol, 2011, 27(1): 68-71+80.
Citation: Kang WenZhen, Huang DeDong, Li Yuan, Zhuang Yan, Zhai Song, Zhao Ke, Xie YuMei, Sun YongTao. HIV-specific cytotoxic T-lymphocyte responses in patients co-infected with HIV and HCV[J]. J Clin Hepatol, 2011, 27(1): 68-71+80.

艾滋病病毒/丙型肝炎病毒双重感染者的艾滋病病毒特异性CTL应答

详细信息
  • 中图分类号: R512.63;R512.91

HIV-specific cytotoxic T-lymphocyte responses in patients co-infected with HIV and HCV

  • 摘要:

    目的探讨中国艾滋病病毒/丙型肝炎病毒(HIV/HCV)双重感染患者HIV特异性细胞毒性T淋巴细胞(CTL)应答的特征。方法观察对象为HIV/HCV双重患者、单纯HIV感染者。以HIV-1 B亚型构建的全基因组肽库作为抗原,通过酶联免疫斑点(ELISPOT)法检测HIV/AIDS患者HIV特异性CTL应答。并对HIV/HCV双重感染患者的HIV特异性CTL应答进行相关性分析。结果 HIV/HCV双重感染组和单纯HIV感染组的HIV特异性CTL应答强度与频率在肽段水平存在一定差异,与单纯HIV感染组相比,合并HCV感染组反应增强的肽段主要集中在Gag。两组特异性CTL应答强度与频率均呈明显正相关,且合并HCV感染组较单纯感染组正相关性增强。不同肽段累计反应强度的比较,Gag反应强度最高,其次是Nef。CD4计数与特异性CTL应答强度的关系无统计学意义。结论 HIV/HCV双重感染患者HCV对HIV进程的影响可能与对Gag蛋白CTL应答的增强有关。

     

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  • 出版日期:  2011-01-20
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