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不同基因型丙型肝炎病毒Core蛋白HLA-DRB1*0311、0401表位预测

程玲 洪国祜 郭艳 毛青

程玲, 洪国祜, 郭艳, 毛青. 不同基因型丙型肝炎病毒Core蛋白HLA-DRB1*0311、0401表位预测[J]. 临床肝胆病杂志, 2011, 27(1): 61-64.
引用本文: 程玲, 洪国祜, 郭艳, 毛青. 不同基因型丙型肝炎病毒Core蛋白HLA-DRB1*0311、0401表位预测[J]. 临床肝胆病杂志, 2011, 27(1): 61-64.
Cheng Ling, Hong GuoHu, Guo Yan, Mao Qing. Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes[J]. J Clin Hepatol, 2011, 27(1): 61-64.
Citation: Cheng Ling, Hong GuoHu, Guo Yan, Mao Qing. Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes[J]. J Clin Hepatol, 2011, 27(1): 61-64.

不同基因型丙型肝炎病毒Core蛋白HLA-DRB1*0311、0401表位预测

详细信息
  • 中图分类号: R512.63

Prediction of HLA-DRB1*0311/0401 in recognizing epitopes of HCV Core protein of different genotypes

  • 摘要:

    目的预测各型丙型肝炎病毒(HCV)Core区的人类白细胞抗原(HLA)-DRB1*0311及0401抗原表位。方法从NCBI数据库中检索出十条包含六种分型的HCV完整氨基酸序列,使用生物信息学工具剪切Core区氨基酸序列并对其二级结构、可塑性、亲水性和抗原性指数进行预测,选择可能区域预测HLA-DRB1*0311及0401的抗原表位。结果 HCV Core区二级结构、可塑性、亲水性和抗原性指数预测分析可认为16~28、60~74、98~120区域或为抗原表位区域。HLA-DRB1*0311预测中,HCV-1a/b、4a、6a预测评分高的区域为28~36,HCV-2a/b为63~71,HCV-3a为29~37,HCV-5a为94~102。HLA-DRB1*0401中,HCV-1a、2b、4a、6a预测评分高区域为84~92,HCV~5a为120~128,HCV-1b中120~128可以预测到表位但评分低。结论 HCV Core区HLA-Ⅱ类分子抗原表位具有型间差异。

     

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  • 出版日期:  2011-01-20
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