40例自体干细胞移植治疗失代偿期肝硬化的临床研究

江军; 范平; 李东良; 陈仕祥; 王梦炎; 何秀华; 何维新; 许婷婷; 陈玺卿; 熊志远; 何志成; 肖兵民

40例自体干细胞移植治疗失代偿期肝硬化的临床研究

1. 解放军第一一三医院肝病科
2. 南京军区福州总医院肝胆内科

详细信息

中图分类号: R575.2
计量
- 文章访问数: 3412
- HTML全文浏览量: 18
- PDF下载量: 776
- 被引次数: 0
出版历程
- 出版日期: 2010-06-20

Autologous stem cells transplantation for treatment of decompensate liver cirrhosis in 40 cases

摘要

摘要: 目的评估自体干细胞移植治疗失代偿期肝硬化的临床效果。方法自体干细胞移植治疗,其中骨髓干细胞移植26例和外周血干细胞移植14例,均接受内科综合治疗。结果患者肝脏的合成功能指标(Alb和PT)、肝功能改善(Alb的增高和CTP评分的减少),从12周始较治疗前有明显变化(P<0.05)。所有患者未出现并发症和不良反应。有1例患者术后32个月死于肝硬化并发症上消化道大出血。结论自体干细胞移植治疗晚期肝硬化是一种安全、有效的治疗方法。
- 干细胞移植 /
- 移植,自体 /
- 肝硬化
Abstract: Objective To evaluate the clinical outcome of autologous stem cells transplantation for the treatment of decompensate liver cirrhosis.Methods 26 patients received bone marrow stem cell transplantation and 14 patients received peripheral blood stem cell transplantation, at the same time all the patients were treated with same medical treatment.Results Since twelve weeks after transplantation, liver synthetic function (serum albumin and prothrombin time) and liver function (serum albumin level increase and CTP score decrease) were significantly improved (P < 0.05) .No related complication or adverse effects were observed in these patients.One patient died of variceal bleeding after 32 months of transplantation.Conclusion Autologous stem cells transplantation might be a safe and effective method for decompensate liver cirrhosis.
- stem cells transplantation /
- transplantation /
- autologous

HTML全文

参考文献(11)

[1]Schwartz RE, Reyes M, Koodie L, et al.Multipotent about progenitor from bone marrow differentiate into functional hepatocyte-like cells[J].J Clin Invest, 2002, 109 (10) ∶1291-1302.

[2]Theise ND, Nimmakayalu M, Gardner R, et al.Liver from bone marrow in humans[J].Hepatology, 2000, 32 (1) ∶11-16.

[3]Yan L, Han Y, Wang J, et al.Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes[J].Am J Hematol, 2007, 82 (11) ∶949-954.

[4] 中华医学会.慢性乙型肝炎防治指南.中华肝脏病杂志[J], 2005, 13 (12) ∶881-891.

[5]Gordon MY, Levicar N, Pai M, et al.Characterization and clinical application of human CD34+stem/progenitor cell population mobilized into the blood by granulocyte colony-stimulating factor[J].Stem cells, 2006, 24 (7) ∶1822-1830.

[6]Furst G, SchulteamEsch J, Poll LW, et al.Poral vein embolization and autologous CD133+bone marrow stem cells for liver regeneration:initial experience[J].Radiology, 2007, 243 (1) ∶171-179.

[7]Shuji T, Tsuyoshi I, Kaoru O, et al.Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy[J].Stem cells, 2006, 24 (7) ∶2292-2298.

[8]Han Y, Yan L, Han G, et al.Controlled trials in hepatitis B virus related decompensate liver cirrhosis:peripheral blood monocyte transplant versus granulocyte-colony-stimulating factor mobilization therapy[J].Cytotherapy, 2008, 10 (4) ∶390-396.

[9]姚鹏, 王帅, 胡大荣, 等.肝动脉自体骨髓干细胞移植治疗失代偿期肝硬化30例[J].世界华人消化杂志, 2005, 13 (13) ∶1639-1640.

[10]Piscaglia AC, Shupe TD, Oh SH, et al.Granulocye-colony stimulating factor promotes liver repair and induces oval cell migration and proliferation in rats[J].Gasteroenterology, 2007, 133 (2) ∶619631.

[11]Armbrust T, Batusic D, Xia L, et al.Early gene expression of hepatocyte growth factor in mononuclear phagocytes of rat liver after administration of carbon tetrachloride[J].Liver, 2002, 22 (6) ∶486494.

施引文献

资源附件(0)

访问统计