瘦素与急性胰腺炎的相关性研究

刘成义; 陈言东

瘦素与急性胰腺炎的相关性研究

包头医学院第二附属医院消化内科

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出版历程
- 出版日期: 2009-06-20

Measurement of serum leptin level in acute pancreatitis patients

摘要

摘要: 目的检测急性胰腺炎（AP）患者血清中瘦素和TNF-α浓度,探讨瘦素与急性胰腺炎及体重指数的关系。方法采用放射免疫法（RIA）检测20例急性胰腺炎患者的血清瘦素和TNF-α的水平,并分析其意义,对照组为37例肥胖者。结果在病例组中,瘦素水平明显高于对照组（P<0.05）,血清瘦素水平与TNF-α、BMI均没有相关（P>0.05）;在对照组中,血清瘦素水平与TNF-α、BMI均呈正相关（P<0.05）。结论AP患者血清瘦素水平显著高于正常健康肥胖者;AP患者血清瘦素含量的增加可能来源于胰腺的释放;血清瘦素是急性胰腺炎生物学指标之一,对损伤的胰腺具有保护作用。
- 瘦素 /
- TNF-α /
- 急性胰腺炎 /
- 体重指数
Abstract: Objective To detect serum levels of leptin and TNF-α and evaluate its clinical significance in acute pancreatitis (AP) and BMI (body mass index) .Methods The serum leptin level and TNF-α were detected by RIA in a total of 20 AP patients.37 obese persons were included in the study as a control group.Results Serum leptin level was significantly higher in AP patients than the control group (p<0.05) .No correlation was observed between the serum level of leptin, TNF-α and BMI in AP patients (p>0.05) and a positive correlation was observed in the control group (p<0.05) .Conclusion Leptin is one of the biological indicators, which has protective effect on AP.Leptin in AP is probably derived from the inflamed pancreas.
- Leptin /
- TNF-α /
- Acute pancreatitis /
- BMI

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参考文献(20)

[1]Zhang Y, roenca R, Maffei M, et al.Positional cloning of the mouse obese gene and its human homologue[J].Nature, 1994, 372 (6505) ∶425-432.

[2]王薇, 李强, 张巾超.瘦素的生物学特性研究现状[J].哈尔滨医科大学学报, 2002, 36 (4) ∶337-338.

[3]Yavuz N, Unal E, Memisoglu K, et al.Plasma leptin levels in rats with panceatitis[J].Tohoku J Exp Med, 2004, 204 (4) ∶243-248.

[4]Konturek PC, Jaworek J, Maniatoglou A, et al.Leptin modulates the inflammatory response in acute pancreatitis[J].Digestion, 2002, 65 (3) ∶149-160.

[5]HotamisligilGS, Shargill NS, Spiegelman BM.Asipose expression of tumor necrosis factor-alpha:direct role in obesity-linked insulin resistance[J].Science, 1993, 259 (5091) ∶87-91.

[6]Grunfeld C, Zhao C, Fuller J, et al.Endotoxin and cytokines induce expression of leptin, the ob gene product in Hamster[J].J Clin In-vest, 1996, 97 (9) ∶2152-2157.

[7]Norman JG, Fink GW, Mcssina J, et al.Timing of tumor necrosisfactor antagonism is critical in determing outcome in murine lethal a-cute pancreatitis[J].Surgery, 1996, 120 (3) ∶515-521.

[8]World Health Organization, Obesity:Preventing and managing the global epidemic[R].Gave WHO, 2000.

[9]Boden G, Chen X, Kolaczynski JW, et al.Effects of prolonged hy-perisuline mia on serum leptin in normal human subjects[J].J Clin Invest, 1997, 100 (5) ∶1107-1113.

[10]Larsson H, Ahren B.Short-term dexamethasone treatment increa-ses plasma leptin independently of changes in insulin sensitivity in healthy wowen[J].J Clin Endocrinol Metab, 1998, 83 (5) ∶1821-1822.

[11]Wand GS, schumann H.Relationship between plasma advenocorti-cotropin, hypothalamic opioid tone, and plasma leptin[J].J Clin Endocrinol Metab, 1998, 83 (6) ∶2138-2142.

[12]Sreenan S.Thyroid dysfunction is not associated with alterations in serum leptin levels[J].Thyroid, 1997, 7 (4) ∶407-409.

[13]Pedersen BK, Bruunsgaard H.Possible benefical role of exercise in modulating low-grade inflammation in the elderly[J].Scand J Med Sci Sports, 2003, 13 (1) ∶56-62.

[14]Finck BN, Johnson RW.Tumor necrosis factor (TNF) =-alpha induces leptin production through the p55TNF receptor[J].AM J Physiol Regul Integr Comp Physiol, 2000, 278 (2) ∶R537-543.

[15]Maruna P, Gurlich R, Frasko R, et al.Serum leptin levels in sep-tic men correlate well with C-reactive protein (CRP) and TNF-al-pha but not with BMI[J].Physiol Res, 2001, 50 (6) ∶589-594.

[16]Ziccardi P, Nappof, Giugliano G, et al.Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women afterweight loss over one year[J].Circulation, 2002, 105 (7) ∶804-809.

[17]Poltout V, Rouault C, Guerre-Millom, et al.Inhibition of insulin secretion by leptin in normal redent islets of langerhans[J].Endocri-nology, 1998, 139 (3) ∶822-826.

[18]Harris DM, Flannigan KL, Go VL, et al.Regulation of cholecysto-kinin-mediated amylase secretion by leptin in rat pancreatic acinar tumor cell line AR42[J].Pancreas, 1999, 19 (3) ∶224-230.

[19]Warzecha Z, Dembinski A, Ceranowicz P, et al.Influence of leptin administration on the course of acute ischemic pancreatitis[J].J Physiol Phaimacol, 2002, 53 (4pt2) ∶775-790.

[20]Tukiainen E, Kylanpaa MU, Ebeling P, et al.Leptin and adipone-ctin levels in acute pancreatitis[J].Pancreas, 2006, 32 (2) ∶211-214.

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