慢性HBV感染者T细胞亚群与CD28亚群的变化

阎双缓; 陈翠英; 曹治宸; 刘金霞

慢性HBV感染者T细胞亚群与CD28亚群的变化

1. 石家庄市第五医院感染五科
2. 河北医科大学第三医院肝病科
3. 承德医学院附属医院

基金项目:

河北省科技厅资助项目(编号07276101D-34)；

详细信息

中图分类号: R512.62
计量
- 文章访问数: 213
- HTML全文浏览量: 23
- PDF下载量: 65
- 被引次数: 0
出版历程
- 出版日期: 2009-05-20

Changes in peripheral T-lymphocytes subsets and CD28 subsets in patients with chronic HBV infected

Research funding:

摘要

摘要: 目的检测不同类型乙型肝炎病毒（HBV）感染者T细胞亚群、CD28功能亚群的特点。方法选择CHB患者20例、肝功能正常的HBV携带者15例、肝功能正常的HBsAg携带者15例,以及健康献血员20例,使用流式细胞仪检测其外周血T细胞亚群及CD28功能亚群。结果CHB患者、HBV携带者CD4+、CD8+、CD4+CD28+及CD8+CD28+T细胞计数均低于正常对照组（P<0.05,P<0.05,P<0.01,P<0.05;P<0.05,P<0.05,P<0.01,P<0.05）;HBsAg携带者CD4+、CD8+、CD4+CD28+及CD8+CD28+T细胞计数与正常对照组无差别（P>0.05）。结论慢性HBV感染者免疫功能不同造成不同形式的慢性感染方式。
- HBV /
- T细胞亚群 /
- CD28亚群 /
- 免疫应答
Abstract: Objective To investigate the changes of T-lymphocyte subsets and CD28 subsets in different types of HBV infected patients.Methods 20 patients with CHB were selected.Simultaneously 15 HBsAg carriers whose liver function were normal were selected.And 20 healthy volunteers were served as normal control.Flow cytometry was used to detect the T-lymphocyte subsets and CD28 functional subsets.Results Compared with normal controls, the numbers of CD4+ T cells, CD4+CD28+T cells and CD8+CD28+T cells decreased in CHB patients and HBV carriers (P<0.05) , whereas there was no significant difference between HBsAg carriers and normal controls (P>0.05) .Conclusion Different immune response resulted in different types of HBV infection.
- HBV /
- T-lymphocyte subsets /
- CD28 subsets /
- immune response

HTML全文

参考文献(9)

[1]中华医学会.慢性乙型肝炎防治指南[J].中华传染病杂志, 2005, 23 (6) :421-431.

[2]田瑛, 邱志峰, 李太生.慢性乙型肝炎患者和乙型肝炎病毒携带者外周血T细胞亚群的变化和意义[J].中华医学杂志, 2005, 85 (47) :3354-3358.

[3]冯慧芬, 张淑凤.慢性HBV感染者外周血淋巴细胞亚群的特征性研究[J].医药论坛杂志, 2007, 28 (6) :32-33.

[4]杜美华, 高涛, 王介非.从淋巴细胞亚群绝对值探讨慢性乙型肝炎细胞免疫[J].Chinese Hepatology, 2006, 11 (4) :260-261.

[5]Guidotti LG, Rochford R, Chung J, et al.Viral clearance without destruction of infected cells during acute HBV infection[J].Sci-ence, 1999, 284 (5415) :825-829.

[6]李乐, 蔡鹏威, 伍严安, 等.慢性乙肝病毒携带者的细胞免疫功能变化及其与血清HBV DNA的关系[J].福建医药杂志, 2003, 25 (6) :18-20.

[7]Acuto O, Michel E.CD28-mediated co-stimulation a quantitative support for TCR signalling[J].Nat Rev Immunol, 2003, 3 (12) :939-951.

[8]Susanne B, Vito R, Cicinnati, et al.Hepatitis B virus-Induce de-fect of monocyter derived dendritic cells leads to impaired T helper type1response in vitro:mechanisms for viral immune escape[J].Immunology, 2003, 109 (4) :487～495.

[9]Appleman L J, Boussiotis V A.Tcell anergy and costimulation[J].Immunol Rev, 2003, 192 (4) :161-180.

施引文献

资源附件(0)

访问统计