氧化苦参碱治疗慢性乙型肝炎致转氨酶反跳的临床意义及相关因素

张学武; 李旭; 胡国启; 李春玉; 周敏

氧化苦参碱治疗慢性乙型肝炎致转氨酶反跳的临床意义及相关因素

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中图分类号: R512.6
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- 出版日期: 2008-01-20

The clinic significance and correlated factors of Alanine Aminotransferase (ALT) flare in patients with chronic hepatitis B treated with Oxymatrine.

摘要

摘要: 目的探讨氧化苦参碱治疗慢性乙型肝炎过程中致ALT反跳的临床意义及影响因素。方法对96例接受氧化苦参碱治疗过程中出现ALT反跳的慢性乙型肝炎患者的临床资料进行分析,观察ALT反跳的临床意义,分析影响ALT的反跳的因素。结果氧化苦参碱治疗慢性乙型肝炎过程中ALT反跳发生率为22.2%;伴有ALT反跳的患者对治疗的完全应答率和持续应答率均高于未发生ALT反跳者(P=0.0010和P=0.0086);ALT反跳的患者HBVDNA下降幅度高于未发生ALT反跳者(P=0.0002、0.0000);ALT反跳发生率与治疗前的HBVDNA水平呈正相关(P=0.0014);联合拉米夫定治疗能降低ALT的反跳率(27.2%vs 11.6%,P=0.002)。结论氧化苦参碱治疗慢性乙型肝炎过程中可发生ALT反跳,其发生与氧化苦参碱抗病毒的应答反应有关。
- 氧化苦参碱 /
- 乙型肝炎 /
- 丙氨酸氨基转移酶 /
- HBVDNA
Abstract: Objective To explore the clinic significance and correlated factors of alanine aminotransferase (ALT) flare in patients with chronic hepatitis B treated with Oxymatrine.Methods By retrospective analysis, we reviewed the clinic datum of 96 chronic hepatitis B patients treated with Oxymatrine, then observed the relationship between ALT flare and the pretreatment ALT level and HBV DNA level compared with patients treated with lamivudine.Results There were 96 patients received Oxymatrine treatment and ALT flare rate was 22.2%.The complete response rate and sustained response rate were higher in the patients with ALT flare than those with no ALT flare, respectively (P=0.0010 and 0.0086) .The HBV DNA decline scope were higher in the patients with ALT flare than the patients with no ALT flare (P=0.0002;0.0000) .ALT flare rate was positively correlated with pre-treatment serum HBV DNA level, but no correlation with pre-treatment ALT level.Combined treatment with Oxymatrine and lamivudine can reduce the ALT flare rate (11.6% vs 27.2%, P=0.002) .Conclusions There were ALT flare in the patients treated with Oxymatrine, and the ALT flares were associated with antivirus response.
- Oxymatrine /
- hepatitis B /
- ALT /
- HBV DNA

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