脂肪肝脂质过氧化与细胞因子TNF-α、IGF-1水平的临床观察

黄妙珍

脂肪肝脂质过氧化与细胞因子TNF-α、IGF-1水平的临床观察

黄妙珍

杭州师范学院附属医院浙江杭州310015

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中图分类号: R575.5
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出版历程
- 出版日期: 2006-03-20

Clinical study of the relationship about fatty liver lipid peroxides with tumor necrosis factor α and insulin-likegrowth factorl.

Huang MiaoZhen

摘要

摘要: 探讨脂肪肝的脂质过氧化与细胞因子的相关性。选择64例脂肪肝患者,测定血清中丙二醛（m alond i-aldehyde,MDA）、超氧化物歧化酶（superoxide d ismutase,SOD）、肿瘤坏死因子α（tumor necrosis factor,αTNF-α）、胰岛素样生长因子1（insu lin-likegrowth factor 1,IGF-1）的水平,并选择56例非脂肪肝的健康人为正常对照。结果显示脂肪肝患者MDA和TNF-α水平升高,与正常组比均为（P<0.05）;SOD和IGF-1水平下降,与正常组比分别为（P<0.05,P<0.01）。提示脂肪肝患者存在脂质过氧化,与TNF-α和IGF-1存在相关性。
- 脂肪肝 /
- 丙二醛 /
- 超氧化物歧化酶 /
- 肿瘤坏死因子 /
- 胰岛素样生长因子
Abstract: To observe as study group the relationship about fatty liver lipid peroxides and cell factor.64 fatty liver cases were selected, the level of MDA、SOD、TNF-α and IGF-1 were tested.56 healthy cases were as contral group.The results demonstrated that the level of MDA and TNF-α were higher, than that of control group (P<0.05, respectively) ;while the l evel of SOD and IGF-1 were lower, than that of control group (P<0.05, P<0.01, respectively) .The study shows that fatty liver exists lipid peroxides and was related to TNF-α and IGF-1.
- fatty liver /
- malondialdehyde /
- superoxide dismutase /
- tumor necrosis factor /
- insulin-likegrowth factor

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参考文献(13)

[1]曾民德.脂肪肝发病机制及其“二次打击”假设[J].中华消化杂志, 2002, 22 (3) ∶167-168.

[2]戴宁, 曾民德, 李继强, 等.非酒精性脂肪肝肝细胞色素P450ⅡE1的表达与氧化抗氧化的关系[J].中华肝脏病杂志, 1999, 7 (2) ∶104-106.

[3]蒋丽珍, 于德民.肿瘤坏死因子α诱发胰岛素抵抗的机理[J].国外医学免疫学分册, 1997, 20 (6) ∶311-313.

[4] Nan ji AA, Khwaja S, Rahem tu lla A, et al.Thromboxane inh ib itorsattenuate pathological changes in alcoholic liver d isease in the rat[J].Gastroenterology, 1997, 112 (1) ∶200-207.

[5]杨彬.胰岛素样生长因子1的研究进展[J].广西医学, 2002, 24 (8) ∶1198-1201.

[6]刘鹂, 韩琴琴, 扬毅, 等.高脂血症血清胰岛素样生长因子Ⅰ水平变化及其对脂代谢的影响[J].中华心血管杂志, 1999, 27 (6) ∶468.

[7]郑雪玲, 赵美恒, 李瑜元, 等.胰岛素样生长因子-Ⅰ与肝硬化[J].国外医学内科学分册, 2000, 22 (2) ∶79-81.

[8] Castilla-CortazarⅠ, Garcia M, Muguerza B, et al.Hepatoprotec-tive effects of insu lin-like growth factorⅠin rats w ith carbon tetra-chloride-induced cirrhosis[J].Gastroenterology.1997, 113 (5) ∶1682-1691.

[9] Ren J, Roughead ZK, W old LE, et al.Increases in insu lin-likegrowth factor-1 level and peroxidative damage after gestational etha-nol exposure in rats[J].Pharmacol Res, 2003, 47 (4) ∶341-347.

[10] Muguerza B, Castilla-CortazarⅠ, Garcia M, Antifibrogen ic effectin vivo of low doses of insu lin-like growth factor-Ⅰin cirrhoticrats[J].B ioch im B iophys Acta.2001, 31∶1536 (2-3) ∶185-195.

[11] Fan J, CharD, Bagby G J, et al.Regu lation of insu lin-like growthfactor-Ⅰ (IGF-Ⅰ) and IGF-b ind ing proteins by tumor necrosisfactor[J].Am J Physiol.1995, 269 (5 Pt 2) ∶1204-1212.

[12] B irdJL, TylerJA.Tumor necrosis factor alpha, interferon gammaand dexam ethasone regu late IGF-1-maintained collagen productionin cu ltured human fibrob lasts[J].JEndocrinol, 1995, 147 (1) ∶167-176.

[13]伍严安, 李德岩, 高春芳, 等.TNF-α拮抗胰岛素样生长因子-1对人α1 (Ⅰ) 胶原启动子的激活[J].第二军医大学学报, 2000, 21 (8) ∶715-717.

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